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L-Epicatechin490-46-0

Name: L-Epicatechin490-46-0
Brand: OORENT
SKU: pr2610191090
Price: 33 USD
Availability: InStock

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Unit Price:

$33-34/MT FOB

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CAS No.:

490-46-0

Grade:

Pharmaceutical Grade

Content:

99.5%

Port:

shanghai

Brand:

OORENT

Packaging:

Vial/Bottle/Bag/Carton

Sample Available:

Yes

Price valid (until):

2026-11-19

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Payment Terms:

100% TT in advance

Average Lead Time:

10 days

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Details
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Inquiry History

Description

Product Detailv

L-Epicatechin Basic information

Product Name:	L-Epicatechin
Synonyms:	3,3',4',5,7-PENTAHYDROXY-FLAVANE;3,3',4',5,7-PENTAHYROXYFLAVONE;3,3',4',5,7-PENTAHYDROXYFLAVAN;(2R,3R)-2-(3,4-DIHYDROXYPHENYL)-3,4-DIHYDRO-1(2H)-BENZOPYRAN-3,5,7-TRIOL;(-)-epicatecho;(-)-epicatechol;EPICATECHIN, (-)-;EPICATECHIN, (+)-
CAS:	490-46-0
MF:	C15H14O6
MW:	290.27
EINECS:	207-710-1
Product Categories:	chemical reagent;pharmaceutical intermediate;Pharmaceutical Raw Materials;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;chiral;Aromatics;Chiral Reagents;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;490-46-0
Mol File:	490-46-0.mol

L-Epicatechin Chemical Properties

Melting point	240 °C (dec.)(lit.)
Boiling point	629.2 °C
alpha	-55~-65゜(D/20℃)(c=1,CH3OH)
density	1.593±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	insoluble in H2O; insoluble in EtOH; ≥14.5 mg/mL in DMSO
form	Solid
pka	9.54±0.10(Predicted)
color	White to Light yellow to Light orange
biological source	green tea
Optical Rotation	Consistent with structure
Water Solubility	Soluble in water or alcohol
Merck	13,1912
BRN	92760
Stability:	Hygroscopic
Major Application	metabolomics vitamins, nutraceuticals, and natural products
Cosmetics Ingredients Functions	ANTIOXIDANT HAIR DYEING ORAL CARE SKIN CONDITIONING - MISCELLANEOUS SKIN PROTECTING DEODORANT ASTRINGENT
InChI	1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2/t13-,15-/m1/s1
InChIKey	PFTAWBLQPZVEMU-UKRRQHHQSA-N
SMILES	O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3ccc(O)c(O)c3
LogP	0.490 (est)
CAS DataBase Reference	490-46-0(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
RTECS	KB3745000
F	10-23
HS Code	29329990
Storage Class	11 - Combustible Solids
Hazard Classifications	Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

MSDS Information

Provider	Language
L-Epicatechin	English
SigmaAldrich	English

L-Epicatechin Usage And Synthesis

Description	(−)-Epicatechin is a polyketide synthase-derived polyphenol flavonoid that has been found in T. cacao and has diverse biological activities. It scavenges DPPH radicals in a cell-free assay when used at a concentration of 5 μM. (−)-Epicatechin inhibits COX-1 (IC₅₀ = 3.2 μM). It acts synergistically with epigallocatechin gallate to induce apoptosis in, and reduce the proliferation of, PC-9 lung cancer cells when used at a concentration of 200 μM. (−)-Epicatechin (80 mg/kg) reduces LPS-induced increases in plasma creatinine and urea levels in a rat model of renal inflammation.
Chemical Properties	white to light yellow crystal powde
Uses	Potent antioxidant and antineoplastic agent.
Uses	An antioxidant and natural product from green tea
Uses	Catechin is a polyphenolic flavonoid that has been isolated from a variety of natural sources including tea leaves, grape seeds, and the wood and bark of trees such as acacia and mahogany. Catechin is a more potent antioxidant than ascorbate or α-tocopherol in certain in vitro lipid peroxidation assays. ()-Epicatechin is a 2R,3R stereoisomer of catechin. Like catechin, ()-epicatechin is a powerful antioxidant. It inhibits cyclooxygenase 1 (IC50 = 3.2 μM). Also, at 100 μM, ()-epicatechin induces apoptosis in human adenocarcinoma PC-9 cells and stimulates the inhibition of tumor necrosis factor-α release from BALB-c/3T3 cells treated with epigallocatechin gallate.
Definition	ChEBI: A catechin with (2R,3R)-configuration.
General Description	()-Epicatechin (EC) belongs to the group of flavanols and is abundantly present in cacao and cacao products. The chemical structure of EC includes an oxygenated heterocycle with a 4-hydroxyl group linked with two aromatic rings.
Biochem/physiol Actions	This antioxidant is found in chocolate. (-)-Epicatechin is linked with cardiovascular effects. It is considered as a dependable standard due to its availability in cacao seeds and cocoa products. The halogenating activity of myeloperoxidase can be restored by (-)-epicatechin.
references	[1]. chakravarthy bk, gupta s, gambhir ss, et al. pancreatic beta-cell regeneration in rats by (-)-epicatechin. lancet, 1981, 2(8249): 759-760. [2]. wippel r, rehn m, gorren ac, et al. interference of the polyphenol epicatechin with the biological chemistry of nitric oxide- and peroxynitrite-mediated reactions. biochem pharmacol, 2004, 67(7): 1285-1295. [3]. brossette t, hundsdörfer c, kröncke kd, et al. direct evidence that (-)-epicatechin increases nitric oxide levels in human endothelial cells. eur j nutr, 2011, 50(7): 595-599. [4]. okushio k, suzuki m, matsumoto n, et al. identification of (-)-epicatechin metabolites and their metabolic fate in the rat. drug metab dispos, 1999, 27(2): 309-316.

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ECHEMI Editorial Reference

(-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

Basic Info

Product Name:

Epicatechin

Other Name:

2H-1-Benzopyran-3,5,7-triol,2-(3,4-dihydroxyphenyl)-3,4-dihydro-,(2R,3R)-;Epicatechol,(-)-;2H-1-Benzopyran-3,5,7-triol,2-(3,4-dihydroxyphenyl)-3,4-dihydro-,(2R-cis)-;(2R,3R)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol;(-)-Epicatechin;(-)-Epicatechol;(-)-(2R:3R)-5,7,3′,4′-Tetrahydroxyflavan-3-ol;Epicatechin;epi-Catechol;l-Epicatechin;l-Epicatechol;Epicatechol;(2R,3R)-(-)-Epicatechin;epi-Catechin;l-Acacatechin;L-Epicatechin;NSC 81161;(-)-epi-Catechin;2545-08-6;863644-83-1;863644-80-8

CAS No.:

490-46-0

Molecular Formula:

C15H14O6

InChIKeys:

InChIKey=PFTAWBLQPZVEMU-UKRRQHHQSA-N

Molecular Weight:

290.27

Exact Mass:

290.27

EC Number:

207-710-1

HScode:

29329990

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

110

XLogP3:

0.4

Appearance:

Solid

Density:

1.6±0.1 g/cm3

Melting Point:

237 °C

Boiling Point:

629.2 °C

Flash Point:

335.0±31.5 °C

Refractive Index:

1.742

Water Solubility:

soluble in water or alcohol

Storage Conditions:

2-8°C

See More Epicatechin Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Epicatechin Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10 days

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

4 Inquiries

Country	Product	Purchase Quantity	Date Posted
Australia	Epicatechin	1 KG	Oct 18, 2026
United States	Nootropics supplements L-Epicatechin 98% Powder Green Tea Extract Ec powder Epicatechin EC POWDER	1000 MT	Nov 3, 2023
India	L-Epicatechin	1 KG	Aug 29, 2024
Sweden	L-Epicatechin 99% powder	500 G	Mar 28, 2024

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L-Epicatechin490-46-0

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