Product Overview

N-Bromosuccinimide (NBS) is an organic compound with the molecular formula C₄H₄BrNO₂ and molecular weight of 177.98 g/mol. This white to pale yellow crystalline solid is one of the most widely used selective brominating agents in organic synthesis. The compound is valued for its mild, selective, and convenient bromination capabilities.

Synthetic Process

• Bromination: Succinimide is brominated using bromine in an alkaline medium

• Purification: The crude product is purified by recrystallization from water

• Drying: The purified product is dried under vacuum

• Quality Control: The final product is analyzed to ensure ≥99.0% purity by titration

Mechanism of Action

• Selective Bromination: Provides a source of electrophilic bromine for allylic and benzylic bromination

• Radical Bromination: Under radical initiation (e.g., AIBN or light), enables Wohl-Ziegler bromination of allylic and benzylic positions

• Oxidation: Can also act as a mild oxidant in certain transformations

Research Applications & Market Significance

• Organic Synthesis: Key reagent for selective bromination of alkenes, arenes, and carbonyl compounds

• Pharmaceutical Research: Used in the synthesis of pharmaceutical intermediates and drug candidates

• Natural Product Synthesis: Essential reagent for selective functionalization in complex molecule synthesis

• Biochemical Research: Used for the modification of tryptophan and other amino acid residues

Quality Specifications

• Purity: ≥99.0% (titration)

• Appearance: White to pale yellow crystalline solid

• Melting point: 174-180°C

• Active bromine: ≥44.5%

• Loss on drying: ≤0.5%

• Storage: 2-8°C, sealed, protected from light and moisture

• Stable for 24 months when properly stored

Packaging & Shipping

• Research quantities: 25g, 100g amber glass bottles

• Bulk quantities: 500g, 1kg amber glass bottles

• Shipped at ambient temperature