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3-Carbamyl-1-methylpyridinium chloride1005-24-9C7H9ClN2O

Name: 3-Carbamyl-1-methylpyridinium chloride1005-24-9C7H9ClN2O
Brand: OORENT
SKU: pr2610211781
Price: 33 USD
Availability: InStock

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Unit Price:

$33-34/MT FOB

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CAS No.:

1005-24-9

Grade:

Pharmaceutical Grade

Content:

99.5%

Port:

shanghai

Brand:

OORENT

Packaging:

Vial/Bottle/Bag/Carton

Sample Available:

Yes

Price valid (until):

2026-11-21

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Payment Terms:

100% TT in advance

Average Lead Time:

10 days

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Details
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Description

Product Detailv

3-Carbamyl-1-methylpyridinium chloride Basic information

Product Name:	3-Carbamyl-1-methylpyridinium chloride
Synonyms:	NICOTINAMIDE CHLOROMETHYLATE;N-METHYLNICOTINIC ACID AMIDE CHLORIDE SALT;N1-METHYLNICOTINAMIDE CHLORIDE;TRIGONELLAMIDE CHLORIDE;3-(aminocarbonyl)-1-methyl-pyridiniuchloride;3-carbamoyl-1-methyl-pyridiniuchloride;nicotinamidemethochloride;nicotinamidemethylchloride
CAS:	1005-24-9
MF:	C7H9ClN2O
MW:	172.61
EINECS:	463-670-7
Product Categories:	Pyridinium Compounds;API
Mol File:	1005-24-9.mol

3-Carbamyl-1-methylpyridinium chloride Chemical Properties

Melting point	207-209℃ (water acetone )
storage temp.	room temp
solubility	H2O: soluble15mg/mL, clear
form	crystalline
color	white
Water Solubility	almost transparency
Merck	14,9693
Cosmetics Ingredients Functions	SKIN CONDITIONING SKIN PROTECTING
InChI	1S/C7H8N2O.ClH/c1-9-4-2-3-6(5-9)7(8)10;/h2-5H,1H3,(H-,8,10);1H
InChIKey	BWVDQVQUNNBTLK-UHFFFAOYSA-N
SMILES	Cl.[n+]1(cc(ccc1)C(=N)[O-])C
CAS DataBase Reference	1005-24-9(CAS DataBase Reference)

Safety Information

WGK Germany	3
RTECS	UU1925000
HS Code	2933.39.9200
Storage Class	11 - Combustible Solids

MSDS Information

Provider	Language
SigmaAldrich	English

3-Carbamyl-1-methylpyridinium chloride Usage And Synthesis

Description	Nicotinamide is a precursor of NAD and NADP , which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide N-methyltransferase (NNMT; ). It demonstrates antithrombotic and anti-inflammatory properties through direct action on the endothelium by a mechanism involving the prostacyclin pathway and by improving nitric oxide bioavailability. Aggressive cancer cell lines are reported to have higher levels of MNA due to increased NNMT-directed transfer of methyl groups from S-adenosyl-L-methionine to nicotinamide, implicating a role for MNA in cancer cell metabolism.
Uses	1-Methylnicotinamide chloride may be used as a standard in the quantification of 1-methylnicotinamide in urine samples using ion pairing reverse-phase high performance liquid chromatography (RP-HPLC).
Uses	Nicotinamide is a precursor of NAD and NADP , which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide N-methyltransferase (NNMT; ). It demonstrates antithrombotic and anti-inflammatory properties through direct action on the endothelium by a mechanism involving the prostacyclin pathway and by improving nitric oxide bioavailability. Aggressive cancer cell lines are reported to have higher levels of MNA due to increased NNMT-directed transfer of methyl groups from S-adenosyl-L-methionine to nicotinamide, implicating a role for MNA in cancer cell metabolism.
General Description	1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT) and exhibits antithrombotic and anti-inflammatory effects.
Biochem/physiol Actions	1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT). 1-Methylnicotinamide (MNA) has been shown to have antithrombotic and anti-inflammatory effects. A recent study indicated that MNA may exert antithrombotic and anti-inflammatory effects through direct action on the endothelium, with a vasorelaxing effect by enhancement of NO bioavailability and reduction of eNOS-dependent oxidative stress. Enhanced NNMT activity is a feature of many types of cancer. How much direct involvement MNA has in the tumorigenesis associated with overexpression of NNMT is under investigation. MNA by itself increased mitochondrial Complex I activity and increased cancer cell viability in SH-SY5Y neuroblastoma cells that do not produce NNMT.
Purification Methods	Recrystallise it from MeOH. [Beilstein 22 III/IV 468, 22/2 V 80.]
References	[1] THEODORE A. ALSTON Robert H A. Substrate specificity of nicotinamide methyltransferase isolated from porcine liver[J]. Archives of biochemistry and biophysics, 1988, 260 2: Pages 601-608. DOI: 10.1016/0003-9861(88)90487-0 [2] TERESA B DOMAGALA. Nitric oxide production and endothelium-dependent vasorelaxation ameliorated by N1-methylnicotinamide in human blood vessels.[J]. Hypertension, 2012, 59 4: 825-832. DOI: 10.1161/hypertensionaha.111.183210 [3] S CHLOPICKI. 1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway[J]. British Journal of Pharmacology, 2009, 152 2: 230-239. DOI: 10.1038/sj.bjp.0707383

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Basic Info

Product Name:

1-Methylnicotinamide chloride

Other Name:

Pyridinium,3-(aminocarbonyl)-1-methyl-,chloride (1:1);3-Carbamoyl-1-methylpyridinium chloride;Pyridinium,3-carbamoyl-1-methyl-,chloride;Pyridinium,3-(aminocarbonyl)-1-methyl-,chloride;3-Carbamyl-1-methylpyridinium chloride;N1-Methylnicotinamide chloride;1-Methylnicotinamide chloride;Trigonellamide chloride;Nicotinamide methochloride;1-Methyl-3-carbamoylpyridinium chloride;3-(Aminocarbonyl)-1-methylpyridinium chloride;N-Methyl-3-carboxamidepyridinium chloride;N-Methylnicotinamide chloride;3-Carbamoyl-1-methylpyridin-1-ium chloride;776318-66-2

CAS No.:

1005-24-9

Molecular Formula:

C7H9N2O.Cl

InChIKeys:

InChIKey=BWVDQVQUNNBTLK-UHFFFAOYSA-N

Molecular Weight:

172.61

Exact Mass:

172.040344

EC Number:

463-670-7

UNII:

L54XNJ1D5G

HScode:

2933399090

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

XLogP3:

-2.68570

Appearance:

white crystalline

Melting Point:

207-209 °C @ Solvent: Water, Acetone

Water Solubility:

H2O: soluble 15mg/mL, clear

Storage Conditions:

room temp

See More 1-Methylnicotinamide chloride Properties 

Hazard Identification

Classification of the substance or mixture

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More 1-Methylnicotinamide chloride Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10 days

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

4 Inquiries

Country	Product	Purchase Quantity	Date Posted
Malaysia	1-Methylnicotinamide Chloride	1 KG	Oct 21, 2026
India	1-Methylnicotinamide chloride	1 KG	Apr 10, 2026
United States	1-Methylnicotinamide Chloride	1 KG	Mar 13, 2026
United States	1 methynicotinamde chloride	1 KG	Nov 12, 2025

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3-Carbamyl-1-methylpyridinium chloride1005-24-9C7H9ClN2O

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