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Artesunate 88495-63-0 C19H28O8

Name: Artesunate 88495-63-0 C19H28O8
Brand: Orient
SKU: pr2512121449
Price: 4 USD
Availability: InStock

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CAS No.:

88495-63-0

Grade:

Industrial Grade

Content:

99%

Port:

shanghai

Brand:

Orient

Packaging:

1KG, 25KG, 200KG, 1000KG, customized

Price valid (until):

2026-01-12

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Focusing on innovative research, development, and production in the field of fine chemicals, we prioritize technology, quality, and market orientation. We collaborate with global partners to build a high-tech chemical industry chain and promote sustainable development in the industry.

The company's main products include pharmaceutical intermediates, food additives, essence, spices and plant extracts. The products have passed international certification and are exported to Europe, America, Japan, South Korea and Southeast Asia.

Artemether Basic information

Product Name:	Artemether
Synonyms:	methyl-dihydroartemisinine;[3r-(3r,5as,6s,8as,9r,10r,12s,12ar**)]-decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12h-pyrano[4,3-j]-1,2-benzodioxepin;ARTEMETHER;ARTHEMETER;Artimether;ArtemetherC16H26O5;cgp56696;dihydroartemisininmethylether
CAS:	71963-77-4
MF:	C16H26O5
MW:	298.37
EINECS:	663-549-0
Product Categories:	Chiral Reagents;Heterocycles;Antimalarial;Intermediates & Fine Chemicals;Pharmaceuticals;chemical reagent;Herb extract;Inhibitor;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;PALUTHER;natural product;API;71963-77-4
Mol File:	71963-77-4.mol

Artemether Chemical Properties

Melting point	86-88°C
alpha	D19.5 +171° (c = 2.59 in CHCl3)
Boiling point	359.79°C (rough estimate)
density	1.0733 (rough estimate)
refractive index	1.6200 (estimate)
storage temp.	room temp
solubility	DMSO: ≥20mg/mL
form	powder
color	off-white to light brown
Optical Rotation	[α]/D +155 to +175°, c = 0.5 in methanol
Merck	14,815
InChI	InChI=1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1
InChIKey	SXYIRMFQILZOAM-HVNFFKDJSA-N
SMILES	O1[C@]23[C@@]4([H])O[C@@](C)(CC[C@@]2([H])[C@H](C)CC[C@@]3([H])[C@@H](C)[C@@H](OC)O4)O1

Safety Information

Hazard Codes	Xn
Risk Statements	22
Safety Statements	24/25
WGK Germany	3
RTECS	KD4165000
HS Code	29329930
Hazardous Substances Data	71963-77-4(Hazardous Substances Data)
Toxicity	LD50 i.m. in mice: 263 mg/kg (China Cooperative Research Group on Qinghaosu)

MSDS Information

Artemether Usage And Synthesis

Description	Artemether is an antiparasitic compound and a derivative of artemisinin . It induces mortality in adult wild-type and pfatp6-mutant P. falciparum but the efficacy is decreased in the mutants (IC₅₀s = 8.2 and 13.5 nM, respectively). Artemether reduces parasitemia in P. falciparum-infected monkeys and P. berghei-infected mice with 50% curative dose (CD₅₀) values of 7.1 and 55 mg/kg, respectively. It also reduces the worm burden of S. mansoni trematodes in mice when used at doses ranging from 200 to 500 mg/kg. Formulations containing artemether have been used in the treatment of malaria.
Chemical Properties	White Solid
Uses	Derivative of Artemisinin (A777500). Antimalarial, used to treat strains of malaria which are multi-drug resistant.
Uses	atypical antidepressant, norepinephrine and dopamine reuptake inhibitor, and nicotinic antagonist
Uses	Artemether and lumefantrine combination therapy is indicated for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum, including malaria acquired in chloroquine-resistant areas. May also be used to treat uncomplicated malaria when
Definition	ChEBI: An artemisinin derivative that is artemisinin in which the lactone has been converted to the corresponding lactol methyl ether. It is used in combination with lumefantrine as an antimalarial for the treatment of multi-drug resistant strains of falcip rum malaria.
General Description	Artemisinin (ART) is a natural compound present in Artemisia annua, a traditional Chinese plant.
Biochem/physiol Actions	Artemether is a methyl ether derivative of artemisinin. It is used against multi-drug resistant strains of the malaria parasite, Plasmodium falciparum, and shows potential in treatment of schistosomiasis.
Safety Profile	Poison by intramuscular route.Experimental reproductive effects. When heated todecomposition it emits acrid smoke and irritating fumes.
target	Antifection
storage	Store at -20°C
References	[1] S H XIAO B A C. In vitro and in vivo studies of the effect of artemether on Schistosoma mansoni.[J]. Antimicrobial Agents and Chemotherapy, 1989, 33 9: 1557-1562. DOI: 10.1128/aac.33.9.1557 [2] DYLAN R PILLAI. Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections.[J]. Malaria Journal, 2012: 131. DOI: 10.1186/1475-2875-11-131 [3] M J SHMUKLARSKY. Comparison of beta-artemether and beta-arteether against malaria parasites in vitro and in vivo.[J]. American Journal of Tropical Medicine and Hygiene, 1993, 48 3: 377-384. DOI: 10.4269/ajtmh.1993.48.377

Product Name:	Artesunate
Synonyms:	ARTENSUNATE;Butanedioic acid, 1-[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl] ester;Artesunate (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-ol hydrogen succinate;ARTESUNATE;ArtesunateC19H28O8;Artemisinin monosuccinate;Artesunic Acid;Butanedioic Acid Mono(3R,5aS,6R,8aS,9R,10R,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl] Ester
CAS:	88495-63-0
MF:	C19H28O8
MW:	384.42
EINECS:	618-170-5
Product Categories:	natural product;Antimalarial;Natural Plant Extract;plant extract;Herb extract;Inhibitors;Active Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals;88495-63-0
Mol File:	88495-63-0.mol

Artesunate Chemical Properties

Melting point	132-1350C
Boiling point	431.1°C (rough estimate)
density	1.2076 (rough estimate)
refractive index	1.4430 (estimate)
Fp	173.5°
storage temp.	2-8°C
solubility	acetone: soluble33.4mg/mL
pka	4.28±0.17(Predicted)
form	crystalline powder
color	white to off-white
biological source	Artemisia annua
Merck	14,818
BCS Class	3/1
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChIKey	FIHJKUPKCHIPAT-AHIGJZGOSA-N
SMILES	C(O[C@@H]1O[C@]2([H])O[C@@]3(C)CC[C@@]4([H])[C@H](C)CC[C@@]([H])([C@H]1C)[C@]42OO3)(=O)CCC(O)=O
LogP	3.291 (est)

Safety Information

Hazard Codes	Xn
Risk Statements	20/21/22
Safety Statements	24/25
WGK Germany	3
HS Code	29419090
Hazardous Substances Data	88495-63-0(Hazardous Substances Data)

MSDS Information

Artesunate Usage And Synthesis

Antiparasitic drug	Artesunate is a kind of commonly used anti-parasitic drug and belongs to reduced artemisinin succinate monoester, and is the derivative of artemisinin containing a sesquiterpene lactone structure, and has a stronger efficacy on treating parasite than artemisinin and is also effective on treating chloroquine resistant strains. It acts on the Plasmodium schizonts on the erythrocytic stage. It takes effect by inhibiting cytochrome oxidase through reduced artemisinin to achievement of the inhibition on the function of cytochrome oxidase of malaria parasite surface membrane-food vacuole membrane, mitochondrial membrane, and thus blocking the supplying of nutrition from the host cell cytoplasm. It has a strong killing effect on the asexual form of plasmodium with a rapid efficacy enabling the rapid control of the onset of malaria. It has good efficacy on treating cerebral malaria, falciparum malaria and vivax malaria with similar efficacy in treating chloroquine-resistant strain of the falciparum malaria, especially with more significant effect on treating cerebral malaria. It can quickly control the emergence of malaria but has no effect on falciparum malaria gametophyte. It has a shorter T1/2 than artemether with blood concentration rapid decreasing after intravenous injection. Its T1/2 is about 30 min. It is widely distributed in the body with the content in intestine, liver, kidney being relative high. Urine and fecal excretion account for only a small fraction. It mainly undergoes metabolic conversion. It is clinically suitable for rescue of critically ill patients with acute malaria and can be used as the first-choice drug for the treatment of patients with cerebral malaria and a variety of dangerous malaria. But its shortcoming is the recrudescence rate. No adverse reactions have been observed at the recommended therapeutic dose; the application of large doses may cause a transient reduction of the outer peripheral reticulocyte which will return to normal level after stopping drug. Women within 2 months of pregnancy should be disabled. Whether it will cause teratogenicity demands further study.
Dosage and administration	Powder: 60mg; each artesunate is also attached with one 5% sodium bicarbonate injection. Upon application, first dissolve the drug in sodium bicarbonate injection, and then diluted to 10 ml with glucose injection after intravenous infusion at a rate of 3~4ml/min. For the treatment of patients of chloroquine-resistant falciparum malaria: 60 mg per time with the first dose being doubled; intravenously inject 1 times per day with 4 days as a course of treatment. The total dose is 300mg. When the symptom gets controlled, you can change with other anti-malarial drugs to reduce the recrudescence rate. The exact dosage and tablets should be according to the exact condition. The above information is edited by the Chemicalbook of Dai Xiongfeng.
Clinical application	The clinical application of artesunate has been as long as ten years. It is made through using the artemisia annua grass which is unique in China as raw material for extracting the active ingredient artemisinin and further going through chemical synthesis. Its major role is in treating plasmodia asexual form. It is also currently the only artemisinin derivatives which can be made into water-soluble formulation. It can be used to kill the parasite in inner phase of red blood cells to achieve the anti-malarial effect, and therefore being used in patients with various types of malaria, especially for treating and saving the patients with anti-chloroquine and anti-piperaquine falciparum malaria and severe-type cerebral malaria. It is characterized by high anti-malarial activity, high rate of fever abatement, short parasite clearance time and low drug toxic and side effects. It is the first-choice of drugs for the treatment of severe malaria. For the application of artesunate tablets, using a total amount of 0.28 g in 3d course of treatment and a total amount of 0.44 g in 5d course of treatment, wherein applying the total amount 0.44 g (equivalent to 8.8 mg/kg) in 5d course for treatment of falciparum malaria can lead to the protozoa recrudescence rate being as low as 4.4% after clinical curing of the patients with no significant toxicity and side effect and no decline in reticulocytes, clarifying that the patients have good tolerance on this dose. Oral administration has low toxicity and rapid efficacy and is more convenient and simple for applying. Applying 0.24 g/kg of artesunate for treatment of 72 cases of chloroquine-resistant falciparum malaria results in both the cooling time and asexual parasite clearance time being within 36 h and severely sicken patients being clinically cured. This clarifies that artesunate injection has many advantages including rapid insecticidal effect, short-term efficacy, safety, etc., it is suitable for the treatment and saving of patients with severe chloroquine-resistant falciparum malaria.

First aid measures

General advice

Consult a physician. Show this material safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Firefighting measures

Suitable extinguishing media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Special hazards arising from the substance or mixture

Carbon oxides Nitrogen oxides (NOx)

Advice for firefighters

Wear self-contained breathing apparatus for firefighting if necessary.

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—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

Artesunate

Other Name:

Butanedioic acid,1-[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl] ester;Butanedioic acid,mono(decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl) ester,[3R-(3α,5aβ,6β,8aβ,9α,10β,12β,12aR*)]-;Butanedioic acid,mono[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl] ester;3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin,butanedioic acid deriv.;Artesunic acid;Artesunate;Qinghaozhi;WR 256283;Arsumax;Dihydroqinghasu hemsuccinate;Plasmotrin;Artesunata;Cosunate;Gsunate Forte;Zysunate;Arinate;Saphnate;Armax 200;Plasmotrim;Asumax;Arsuamoon;α-Artesunic acid;Artecan;NSC 712571;HC 101B;83507-69-1;91487-94-4;112346-66-4;252637-87-9;1177476-35-5;1236362-31-4

CAS No.:

88495-63-0

Molecular Formula:

C19H28O8

InChIKeys:

InChIKey=FIHJKUPKCHIPAT-AHIGJZGOSA-N

Molecular Weight:

384.42

Exact Mass:

384.42

EC Number:

1312995-182-4

NSC Number:

712571

DSSTox ID:

DTXSID3042681

Color/Form:

Fine white crystalline powder

ATC Code:

P - Antiparasitic products, insecticides and repellents

HScode:

29419090

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

101

XLogP3:

log Kow = 2.61 (est)

Appearance:

white to off-white

Density:

1.2076 (rough estimate)

Melting Point:

140-142 °C

Boiling Point:

502.1°C at 760 mmHg

Flash Point:

173.5ºC

Refractive Index:

1.543

Water Solubility:

acetone: soluble 33.4mg/mL

Storage Conditions:

room temp

Vapor Pressure:

3.2X10-9 mm Hg at 25 °C (est)

Henrys Law Constant:

Henry's Law constant = 3.8X10-15 atm cu m/mol at 25 °C (est)

Dissociation Constants:

pKa = 4.35 (est)

Experimental Properties:

Poor stability in aqueous solutions /Artesunate sodium salt/|Hydroxyl radical reaction rate constant = 5.6X10-11 cu cm/molec-sec at 25 °C (est)

See More Artesunate Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

Acute toxicity - Category 4, Dermal

Acute toxicity - Category 4, Inhalation

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed H312 Harmful in contact with skin H332 Harmful if inhaled
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P317 Get medical help. P321 Specific treatment (see ... on this label). P362+P364 Take off contaminated clothing and wash it before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Artesunate Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
Pakistan	ARTESUNATE	1 KG	Sep 30, 2024

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Artesunate 88495-63-0 C19H28O8

Product Description

Seller Information

Inquiry History

First aid measures

Firefighting measures

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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