Retatrutide 99% White raw powder High Quality reta weight loss Pharmacy GradeIn stock, fast delivery.

  Name:Helen
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Retatrutide (LY3437943) acetate is a triple agonist peptide for the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide acetate inhibits human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643, and 0.775 nM, respectively. It exhibits activity on mouse GCGR, GIPR, and GLP-1R with EC50 values of 2.32, 0.191, and 0.794 nM, respectively. In vivo, Retatrutide (LY3437943) acetate engages with GCGR and enhances glucose tolerance in an ipGTT by acting through GIP or GLP-1 receptors. Activation via the glucagon receptor by Retatrutide acetate leads to significant weight reduction and increased energy expenditure. Retatrutide acetate can be utilized in research related to obesity.

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Our team of experienced professionals is committed to delivering innovative solutions and exceptional customer service. We work closely with our clients to understand their unique needs and develop customized products to meet their specific requirements. With a state-of-the-art manufacturing facility and strict quality control measures, we ensure that our products meet the highest standards of safety and purity.



Characteristics
Water Solubility:Soluble in water (5mg/ml).
Storage Conditions:-20°C
Critical Temperature & Pressure:-20°C

Research
Class:Triple agonist — GCGR, GIPR, GLP-1R
Status:Investigational (Phase 3)
Mechanism:Simultaneously activates glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Engineered from the native GIP backbone with amino acid substitutions to confer GCGR and GLP-1R activity.Simultaneously activates glucagon receptor (…
EC50 (Human GCGR):5.79 nM
EC50 (Mouse GIPR):0.191 nM
EC50 (Mouse GLP1R):0.794 nM
EC50 (Mouse GCGR):2.32 nM
EC50 (Human GLP1R):0.775 nM
EC50 (Human GIPR):0.0643 nM
Source:Jastreboff AM, et al. N Engl J Med. 2023;389(6):514-526.Jastreboff AM, et al. N Engl J Med. 2023;389(…DOI
Clinical Development:NCT04881760; NCT05882045; NCT06354660

References
ChEMBL:CHEMBL5095485
DrugBank:DB18993
KEGG DRUG:D12430
PubChem:PubChem
Literature:NEJM: Jastreboff et al. (2023) — Phase 2 Trial; FDA Drugs@FDA
Disclaimer:Retatrutide is an investigational compound not yet approved by FDA or EMA. This listing is for industrial and laboratory research use only. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
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United States, United Kingdom, Canada, etc., can guarantee 10-12days to receive goods
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1.Can we get your free samples?
Yes, can. Our free sample can be provided for customers test. But the freight for express is obuyer's account.
2.Can we do printing or label on the bottles?
Yes, can. We can offer various printing ways,such, screen printing, hot stamping, label printing.
3.What is the normal lead time?
For stock products, within 24-48 hours after we receive your payment. For smaller customize color bottles, we will ship out within 3-5 days.
4.What is your shipping terms?
Faster ways: FEDEX, DHL, UPS, TNT, etc by sea or by air economy
5.How does your factory do regarding quality control?
We do test for 3 times before packing.

1.COA/MSDS/ROS/MOA Available.
2.Any inquiries will be replied within 12 hours.
3. Dedication to quality, supply & service.
4.Strictly on selecting raw materials.
5.Reasonable & competitive price, fast lead time.
6.Faster delivery:Sample order in stock and one week for bulk production.
7.We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder.
8.Timely after-service resolves your worry for internation trade.
Welcome to be our distinguished customer, please do not hesitate to contact us!