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Thiabendazole 148-79-8

Name: Thiabendazole 148-79-8
Brand: orient
SKU: pr2611051679
Price: 45 USD
Availability: InStock

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Unit Price:

$45-56/MT FOB

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CAS No.:

148-79-8

Grade:

Industrial Grade

Content:

99%

Port:

Brand:

orient

Packaging:

1KG, 5KG, 25KG

Sample Available:

Yes

Price valid (until):

2028-05-26

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Payment Terms:

100% TT in advance

Average Lead Time:

10 days

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Details
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Inquiry History

Description

Product Name:	Dermorphin
Synonyms:	DERMORPHIN ACETATE;L-Tyr-D-Ala-L-Phe-Gly-L-Tyr-L-Pro-L-Ser-NH2;Tyrosyl-alanyl-phenylalanyl-glycyl-tyrosyl-prolyl-serinamide;Dermorphin trifluoroacetate salt;Dermorphin Powder;(2S)-N-[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carboxamide;Dermorphin HAc;(2S)-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenyl-propanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]-N-[(1S)-1-carbamoyl-2-hydro
CAS:	77614-16-5
MF:	C40H50N8O10
MW:	802.87
EINECS:	202-853-6
Product Categories:	77614-16-5
Mol File:	77614-16-5.mol

Dermorphin Chemical Properties

Melting point	157-159 °C
Boiling point	1323.8±65.0 °C(Predicted)
density	1.363±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO
form	powder
pka	9.83±0.15(Predicted)
color	white to off-white
Sequence	H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2
InChIKey	FHZPGIUBXYVUOY-VWGYHWLBSA-N
SMILES	C(N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N)(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](C)NC(=O)[C@@H](N)CC1C=CC(O)=CC=1)CC1C=CC=CC=1)CC1C=CC(O)=CC=1

Safety Information

WGK Germany

MSDS Information

Dermorphin Usage And Synthesis

Structure	Dermorphin does not contain the common N-terminal sequence for the traditional endogenous peptides (Tyr–Gly–Gly–Phe), and its sequence is completely different from those of the endomorphins, which were identified as endogenous μ- peptides that also do not contain the common sequence. Interestingly, DM contains D-alanine (a D-isomer amino acid) in its sequence. The primary structure of dermorphin is YDAFGYPS-NH2.
Description	Dermorphin was first isolated from the skin of the skin of South American frogs of the genus Phyllomedusa. It is a high potency natural opiate peptide that binds selectively to mu- receptors.
Uses	A mu- receptor agonist
Definition	ChEBI: Dermorphin is an oligopeptide.
Side effects	Like μ-opiate agonists, dermorphins produce antinociception and also catalepsy, respiratory depression, constipation, tolerance, and dependence, although at a lower degree than does[1].
in vitro	Dermorphin, a peptide isolated from the skin of Phyllomedusa frogs and the peptide receptor (NOP) component by the endogenous agonist nociceptin/orphanin FQ (N/OFQ). In displacement binding studies at CHOhMu, Dermorphin and DeNo displac the binding of [3H]-DPN in a concentration dependent and saturable manner. Dermorphin displays an affinity of 7.17, while N/OFQ fails to displace [3H]-DPN at the Delta receptor. Dermorphin and DeNo stimulate the binding of GTPγ[35S] in a concentration dependent and saturable manner at the Mu receptor.
References	[1] Negri, L. P. Melchiorri and R. Lattanzi. “ and Bv8 Peptides.”Handbook of Biologically Active Peptides (Second Edition) 2013:376-383.

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

Q4:What if there are quality issues？

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

ECHEMI Editorial Reference

Thiabendazole, as a member of the benzimidazole class of compounds, is unique in that it carries a 1,3-thiazole-4-yl substituent at position 2. This compound has demonstrated significant fungicidal effects in the agricultural field, particularly in the post-harvest stage, with excellent control over a range of pathogens such as Aspergillus, Botrytis, Cladosporium, and Phytophthora. Thiabendazole typically appears as a white or cream-colored odorless powder that sublimes at temperatures above 590°F and emits a bright light in acidic solutions. Its applications are widespread, and it can be applied in the form of dust, flowing powder, or water-dispersible powder to ensure systemic control of fungi and parasites. The background of the drug's development is also noteworthy. As a 2-substituted benzimidazole drug, it was first introduced in 1962 and quickly became the preferred treatment for a range of nematode infections, particularly in the treatment of strongyluria. However, Thiabendazole is not without side effects, and it may have adverse effects on the central nervous system and potentially exhibit liver toxicity, as detailed in Smith and Leonard's "Pharmacology" (1992 edition, page 919). Despite Thiabendazole's former prominence in the treatment of intestinal threadworms and strong linear worm infections, its status has been challenged in recent years with the emergence of more tolerant drugs. In particular, the potential for liver damage, while rare but potentially serious, has accelerated the development and application of alternative drugs. As for the mechanism of action of Thiabendazole, while it is not yet fully understood, studies have shown that it can inhibit the parasite-specific mitochondrial enzyme succinate dehydrogenase, thereby disrupting the citric acid cycle, mitochondrial respiration, and ATP production, ultimately leading to the death of the parasite. Additionally, Thiabendazole is thought to inhibit microtubule polymerization by binding to β-tubulin, thereby exerting ovicidal effects on certain nematodes. These findings provide valuable insights into the pharmacological action of Thiabendazole.

Basic Info

Product Name:

Thiabendazole

Other Name:

1H-Benzimidazole,2-(4-thiazolyl)-;Benzimidazole,2-(4-thiazolyl)-;2-(4-Thiazolyl)-1H-benzimidazole;MK 360;Mintezol;Thiabendazole;Thiabenzole;2-(4-Thiazolyl)benzimidazole;TBZ 60W;Mertect 160;Mertect;TBZ;Thiabendazol;Tecto;Thibenzol;2-(4′-Thiazolyl)benzimidazole;Equizole;Tecto 60;Mintesol;Thibenzole;Thibenzole 200;Tiabendazol;Tiabendazole;Minzolum;Triasox;Omnizole;Tiabenda;Metasol TK 100;Tebuzate;TBZ 6;Tecto 40F;Tecto 10P;Tibimix 20;Thibendole;Thiabendole;Sistesan;Sanaizol 100;MSD 18;Chemviron TK 100;Tecto B;5-(4-Thiazolyl)benzimidazole;G 491;Storite;Ormogal;Cropasal;Mertect 340F;Tectab;Tecta;Pitrizet;Mertect LSP;Hokkustar HP;Hokustar HP;Syntol M 100;Drawipas;TBZ (fungicide);2-(4′-Thiazoyl)benzimidazole;2-(4-Thiazolyl)-1H-benzoimidazole;Amolden HS;2-(4-Triazolyl)benzimidazole;Bovizole;Lombristop;Polival;Top Form Wormer;Thiaben;Eprofil;Nemapan;Sanaizol TBZ-FL 25;NSC 525040;NSC 90507;Marukacide M 101;2-(1,3-Thiazol-4-yl)-1H-benzimidazole;Metasol TK 25AD;TK 25AD;Irgaguard F 3000;Metasol TK 25;4-(1H-Benzimidazol-2-yl)thiazole;Metasol TK 50AD;2-(4-Thiazoyl)benzimidazole;Biogard TBH;2-(1,3-Thiazol-4-yl)benzimidazole;2-(1,3-Thiazol-4-yl)-1H-1,3-benzodiazole;Neo-Sintol AF 75;94977-06-7;98002-42-7;123242-33-1;8018-04-0;8027-10-9;8028-27-1;145316-67-2;1135441-27-8

CAS No.:

148-79-8

Molecular Formula:

C10H7N3S

InChIKeys:

InChIKey=WJCNZQLZVWNLKY-UHFFFAOYSA-N

Molecular Weight:

201.25

Exact Mass:

201.25

EC Number:

205-725-8

UNII:

N1Q45E87DT

NSC Number:

757347|525040|90507

UN Number:

3077|2588

DSSTox ID:

DTXSID0021337

NCI Thesaurus Code:

C873

Color/Form:

Colorless crystals|White crystals|Off-white powder|White to practically white powder|White to tan crystals

ATC Code:

D - Dermatologicals|P - Antiparasitic products, insecticides and repellents

HScode:

29341000

Categories:

Inhibitor Drugs

Characteristics

PSA:

69.8

XLogP3:

2.2

Appearance:

light yellow powder

Density:

1.2271 (rough estimate)

Melting Point:

304-305 °C

Boiling Point:

446.0±37.0 °C(Predicted)

Flash Point:

226.2±16.9 °C

Refractive Index:

1.5500 (estimate)

Water Solubility:

H2O: 0.005 g/100 mL;soluble in methanol and dimethyl sulfoxide.

Storage Conditions:

0-6°C

Vapor Pressure:

Negligible at room temperature

Toxicity:

Oral-Rat LD50: 2080 mg/kg; Oral-Mouse LD50: 1300 mg/kg

Flammability characteristics:

Combustion produces toxic nitrogen oxide and sulfur oxide gas

Odor:

Odorless

Taste:

Tasteless

PKA:

4.64(at 25 °C)

Henrys Law Constant:

Henry's Law constant = 2.12X10-11 atm-cu m/mol at 25 °C (est)

Dissociation Constants:

4.64 (at 25 °C)|pKa = 4.64

Collision Cross Section:

164.17 Å² [M+Na]+ [CCS Type: DT, Method: stepped-field]|144.6 Å² [M-H]- [CCS Type: DT, Method: stepped-field]|137.7 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]|136.19 Å² [M+H]+ [CCS Type: TW]|138.9 Å² [M+H]+ [CCS Type: DT, Method: single field calibrated]|141.7 Å² [M+H]+ [CCS Type: TW, Method: calibrated with Waters Major Mix]|152.4 Å² [M+Na]+ [CCS Type: TW, Method: calibrated with Waters Major Mix]|141.71 Å² [M-H]-|144.1 Å² [M-H]-

Experimental Properties:

Nonhygroscopic|Sublimes when heated strongly to 310 °C|Hydroxyl radical reaction rate constant = 6.5X10-11 cu cm/molec-sesc at 25 °C (est)

Air and Water Reactions:

Insoluble in water.

Reactive Group:

Amines, Phosphines, and Pyridines

Reactivity Profile:

THIABENDAZOLE is incompatible with a number of pesticides, including copper-containing fungicides, and with highly alkaline materials. It is a chelating agent, binding many metals including iron, but not calcium (NTP, 1992)

See More Thiabendazole Properties 

Hazard Identification

Classification of the substance or mixture

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H410 Very toxic to aquatic life with long lasting effects
Prevention	P273 Avoid release to the environment.
Response	P391 Collect spillage.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Thiabendazole Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10 days

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

9 Inquiries

Country	Product	Purchase Quantity	Date Posted
Canada	Thiabendazole	200 G	Nov 5, 2026
Paraguay	D(+)-Glucose	10000 KG	Aug 28, 2026
Paraguay	Isopropyl alcohol	16000 KG	Aug 28, 2026
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Paraguay	Xylene	16000 KG	Aug 28, 2026
Paraguay	Trisodium citrate dihydrate	1000 KG	Aug 28, 2026
Paraguay	Penicillin G sodium salt	100 KG	Aug 28, 2026
Kazakstan	Thiabendazole-D₃	1 KG	Apr 27, 2026
United Kingdom	Thiabendazole	25 KG	Jan 22, 2025

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Thiabendazole 148-79-8

Product Details

Seller Information

Inquiry History

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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