8-Bromo-7-methoxyquinoline

4.2 g of RL-0107 was placed in a 100 mL three-necked flask, and N-bromosuccinimide (NBS) was added thereto. Further, 60 mL of dichloromethane was added, and argon gasReplacement was done. The reaction was further carried out at room temperature for 12 hours. After completion of the reaction, sodium thiosulfate (Na2S 2 O 3) was added and extracted with a water / ethyl acetate system. The organic layer was collected, dried over anhydrous magnesium sulfateAfter drying, the solvent was removed and purified by column chromatography to obtain 5.9 g of RL-0106(Yield: about 93.1percent).4.2 g of RL-0107 was placed in a 100 mL three-necked flask, and N-bromosuccinimide (NBS) was added thereto. Further, 60 mL of dichloromethane was added, and argon gasReplacement was done. The reaction was further carried out at room temperature for 12 hours. After completion of the reaction, sodium thiosulfate (Na2S 2 O 3) was added and extracted with a water / ethyl acetate system. The organic layer was collected, dried over anhydrous magnesium sulfateAfter drying, the solvent was removed and purified by column chromatography to obtain 5.9 g of RL-0106(Yield: about 93.1percent).

Molecular Weight:238.08
XLogP3:2.9
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:236.97893
Monoisotopic Mass:236.97893
Topological Polar Surface Area:22.1
Heavy Atom Count:13
Complexity:176
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes