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Home > Encyclopedia > 7-Hydroxyrisperidone

7-Hydroxyrisperidone

pharmaceutical raw materials
7-Hydroxyrisperidone structure

7-Hydroxyrisperidone 

structure
  • CAS No:

    147663-04-5

  • Formula:

    C23H27FN4O3

  • Chemical Name:

    7-Hydroxyrisperidone

  • Synonyms:

    4H-Pyrido[1,2-a]pyrimidin-4-one,3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-7-hydroxy-2-methyl-;1,2-Benzisoxazole,4H-pyrido[1,2-a]pyrimidin-4-one deriv.;3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-7-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one;R 79242;7-Hydroxyrisperidone;130049-90-0

  • Categories:

    Active Pharmaceutical Ingredients  >  Nervous System Drugs

Description

White to Off-White Solid


A benzisoxazole derivative and active metabolite of RISPERIDONE that functions as a DOPAMINE D2 RECEPTOR ANTAGONIST and SEROTONIN 5-HT2 RECEPTOR ANTAGONIST. It is an ANTIPSYCHOTIC AGENT used in the treatment of SCHIZOPHRENIA.

7-Hydroxyrisperidone Basic Attributes

426.48

426.48

DTXSID50332989

Characteristics

82.2

1.7

1.45±0.1 g/cm3(Predicted)

151-153°C

612.3±65.0 °C(Predicted)

324.1ºC

1.691

-20°C Freezer

7.54E-16mmHg at 25°C

Drug Information

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)|Compounds and drugs that bind to and inhibit or block the activation of DOPAMINE D2 RECEPTORS. (See all compounds classified as Dopamine D2 Receptor Antagonists.)|Drugs that bind to but do not activate SEROTONIN 5-HT2 RECEPTORS, thereby blocking the actions of SEROTONIN or SEROTONIN 5-HT2 RECEPTOR AGONISTS. Included under this heading are antagonists for one or more specific 5-HT2 receptor subtypes. (See all compounds classified as Serotonin 5-HT2 Receptor Antagonists.)

9-Hydroxy-risperidone is a known human metabolite of risperidone.

3-(2-(4-(6-fluoro-3-(1,2-benzisoxazolyl))-1-piperidinyl)ethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido(1,2-a)pyrimidin-4-one

7-Hydroxyrisperidone Use and Manufacturing

A metabolite of Risperidone (R525000), a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.

Computed Properties

Molecular Weight:426.5
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:426.20671890
Monoisotopic Mass:426.20671890
Topological Polar Surface Area:82.2
Heavy Atom Count:31
Complexity:764
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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