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Fluvoxamine maleate

Fluvoxamine maleate structure

CAS No:
61718-82-9
Formula:
C15H21F3N2O2.C4H4O4
Chemical Name:
Fluvoxamine maleate
Synonyms:
1-Pentanone,5-methoxy-1-[4-(trifluoromethyl)phenyl]-,O-(2-aminoethyl)oxime,(1E)-,(2Z)-2-butenedioate (1:1);1-Pentanone,5-methoxy-1-[4-(trifluoromethyl)phenyl]-,O-(2-aminoethyl)oxime,(E)-,(Z)-2-butenedioate (1:1);Fluvoxamine maleate;Faverin 50;Luvox;DU 23000;Avoxin;Avoksin;Depromel;Fevarin;Dumirox;MK 264;Floxyfral;Maveral;Faverin;NSC 309469;Faverine;54739-20-7
Categories:
Active Pharmaceutical Ingredients > Inhibitor Drugs

Description

Fluvoxamine maleate is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor.Target: SSRIsFluvoxamine (maleate) is the maleate salt form of fluvoxamine, which is effective in inhibiting 5-HT uptake by blood platelets and brain synaptosomes. The antagonism by fluvoxamine of the reserpine-induced lowering of the pentamethylenetetrazole convulsive threshold can be regarded as due to an effect upon 5-HT uptake. In contrast to the effects of desmethyl

A selective serotonin reuptake inhibitor that is used in the treatment of DEPRESSION and a variety of ANXIETY DISORDERS.

Fluvoxamine maleate Basic Attributes

Molecular Weight：

434.41

Exact Mass：

434.166473

EC Number：

228-994-3

DSSTox ID：

DTXSID3042558

HScode：

2928000090

Characteristics

PSA：

131 Å²

XLogP3：

3.61360

Appearance：

solid

Melting Point：

120-121.5 °C

Boiling Point：

370.6°C at 760 mmHg

Flash Point：

9℃

Water Solubility：

H2O: soluble

Storage Conditions：

2-8°C

Safety Information

Transport codes：

UN1230 - class 3 - PG 2 - Methanol, solution

wgk germany：

hazard class code：

22-36/37/38

safety instructions：

36-36/37/39-27-26

RTECS Number：

SA9230000

Marks：

Xn,Xi

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

GHS Classification：

|Danger|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P273, P280, P301+P312, P304+P312, P304+P340, P305+P351+P338, P310, P312, P330, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 199 companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake. (See all compounds classified as Antidepressive Agents, Second-Generation.)|Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)|Compounds that specifically inhibit the reuptake of serotonin in the brain. (See all compounds classified as Serotonin Uptake Inhibitors.)|Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP1A2. (See all compounds classified as Cytochrome P-450 CYP1A2 Inhibitors.)|Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP2C19. (See all compounds classified as Cytochrome P-450 CYP2C19 Inhibitors.)

MeSH Entry Terms：

Desiflu

Fluvoxamine maleate Use and Manufacturing

Methods of Manufacturing

Preparation of Crude Fluvoxamine Maleate Formula I (0046) To a prepared solution of dimethyl sulphoxide (575 ml), potassium hydroxide flakes (114.64 gm) and water (69 ml), stage-1 (115 gm) was added at temperature 40-45° C. The reaction mixture was stirred to get clear solution followed by adding 2-chloroethylamine hydrochloride (8636 gm) drop wise into the reaction mixture at temperature 40-45° C. and maintained for 1-2 hour. Water (1150 ml) was added in to the reaction mixture at temperature 25-30° C. and stirred for 20-25 minutes. Then toluene (575 ml×2) was added and stirred for 30 minutes and preceded for separation of layers followed by washing the toluene layer with water (1150×5 ml). The solution of maleic acid (48.47 gm) dissolved in water (98 ml) was added into above obtained toluene layer and stirred at temperature 25-30° C. for 2-3 hours. The reaction mixture was cooled to 0-5° C. and maintained for 30-40 minutes at the same temperature. The obtained material was washed with toluene, filtered and such dried. The wet cake was then added hexane (600 ml) and stirred for 30 minutes at temperature 25-30° C., filtered, washed with hexane and dried to get 161 gm of title compound. HPLC purity: >98.5percent

Uses

Anxiety disorder

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:434.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:11
Exact Mass:434.16647101
Monoisotopic Mass:434.16647101
Topological Polar Surface Area:131
Heavy Atom Count:30
Complexity:446
Undefined Bond Stereocenter Count:2
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Pharmacological action not specified

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Fluvoxamine Maleate Tablets
Specifications	50mg

Fluvoxamine Maleate Tablets
Ingredients	Fluvoxamine Maleate
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	50 mg

Fluvoxamine Maleate

See More Related Drugs

Registered Holders

DASAMI LAB PRIVATE LTD

United States
Active
APOTEX PHARMACHEM INDIA PVT LTD

United States
Active
ALIVUS LIFE SCIENCES LTD

United States
Active

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