Thiethylperazine maleate
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Thiethylperazine maleate
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CAS No:
1179-69-7
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Formula:
C22H29N3S2.2C4H4O4
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Chemical Name:
Thiethylperazine maleate
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Synonyms:
10H-Phenothiazine,2-(ethylthio)-10-[3-(4-methyl-1-piperazinyl)propyl]-,(2Z)-2-butenedioate (1:2);Phenothiazine,2-(ethylthio)-10-[3-(4-methyl-1-piperazinyl)propyl]-,maleate (1:2);10H-Phenothiazine,2-(ethylthio)-10-[3-(4-methyl-1-piperazinyl)propyl]-,(Z)-2-butenedioate (1:2);Phenothiazine,2-(ethylthio)-10-[3-(4-methyl-1-piperazinyl)propyl]-,dimaleate;GS 95;2-Ethylmercapto-10-[3-(1-methyl-4-piperazinyl)propyl]phenothiazine dimaleate;2-(Ethylthio)-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine dimaleate;Thiethylperazine maleate;Thiethylperazine dimaleate;Torecan;Toresten;NSC 130044;Tresten;Torecan maleate
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CAS No:
Description
A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457)
Characteristics
209.52000
4.40320
Solid
1.24g/cm3
188-190 °C (decomp)
559.8ºC at 760 mmHg
292.4ºC
0.0584 mg/L
Safety Information
SP0350000
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P273, P301+P312, P330, P391, and P501|Aggregated GHS information provided by 5 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)|Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)
Norzine
Thiethylperazine maleate Use and Manufacturing
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:631.8
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:10
Exact Mass:631.20220749
Monoisotopic Mass:631.20220749
Topological Polar Surface Area:210
Heavy Atom Count:43
Complexity:574
Undefined Bond Stereocenter Count:2
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes
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