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Metapramine

Metapramine structure

CAS No:
21730-16-5
Formula:
C16H18N2
Chemical Name:
Metapramine
Synonyms:
5H-Dibenz[b,f]azepin-10-amine,10,11-dihydro-N,5-dimethyl-;5H-Dibenz[b,f]azepine,10,11-dihydro-5-methyl-10-(methylamino)-;10,11-Dihydro-N,5-dimethyl-5H-dibenz[b,f]azepin-10-amine;5-Methyl-10-methylamino-10,11-dihydrodibenzo[b,f]azepine;Metapramine;RP 19560;115330-71-7
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

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Description

Metapramine is a dibenzooxazepine.

Metapramine Basic Attributes

Molecular Weight：

238.334

Exact Mass：

238.33

HScode：

2933990090

Characteristics

PSA：

15.3

XLogP3：

3.72700

Density：

1.12g/cm3

Melting Point：

237-240 °C

Boiling Point：

350.8ºC at 760mmHg

Flash Point：

140.7ºC

Refractive Index：

1.633

Drug Information

MeSH：

Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system. (See all compounds classified as Antidepressive Agents, Tricyclic.)

MeSH Entry Terms：

15-methyl-10-methylamino-10,11- dihydrodibenzo(b,f)-azepine

Metapramine Use and Manufacturing

Metapramine is a tricyclic antidepressant derived from dibenzoazepine. Metapramine acts as a norepinephrine reuptake inhibitor without affecting the reuptake of serotonin or dopamine.

Computed Properties

Molecular Weight:238.33
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:238.146998583
Monoisotopic Mass:238.146998583
Topological Polar Surface Area:15.3
Heavy Atom Count:18
Complexity:278
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes