2,4-Dichloro-6,7-dimethoxyquinazoline
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2,4-Dichloro-6,7-dimethoxyquinazoline
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CAS No:
27631-29-4
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Formula:
C10H8Cl2N2O2
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Chemical Name:
2,4-Dichloro-6,7-dimethoxyquinazoline
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Synonyms:
Quinazoline,2,4-dichloro-6,7-dimethoxy-;2,4-Dichloro-6,7-dimethoxyquinazoline;2-Chloro-6,7-dimethoxyquinazolin-4-yl chloride
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CAS No:
2,4-Dichloro-6,7-dimethoxyquinazoline Basic Attributes
259.09
259.09
190331
0
B6720H065I
DTXSID00182012
2933990090
Characteristics
44.2
3.4
Pale yellow to beige Crystalline Powder
1.4±0.1 g/cm3
158 °C
340.512°C at 760 mmHg
159.7±27.9 °C
1.614
Insoluble in water.
0mmHg at 25°C
Safety Information
NONH for all modes of transport
3
36/37/38
37/39-26-36
Xi
P261-P305 + P351 + P338
H315-H319-H335
|Warning|H315 (97.87%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 47 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
2,4-Dichloro-6,7-dimethoxyquinazoline Use and Manufacturing
General procedure: In a 100mL flask equipped with a reflux condenser, the reaction mixture containing the quinazolinediones (1.00g) and POCl[00101] 8 gr, 36 [MM, ] 6, 7-dimethoxy 2, 4-quinazoline dione, 23 ml, 280 nM [POC13] and 10 ml dimethyl aniline in 40 ml toluene were refluxed for 5 hours. Water and NH3 were added and the reaction was filtered and washed with [ETOAC] to give 7g light-green solid, mp-1560. 75percent yield. HPLC-97percent pure, Rt=4.87 minutes (RP 18, CH3CN: H20 70: 30, [W=254] [FLOW=1.] 0). NMR CDC13 8 7.36 [(LH, ] s), 7.28 [(LH, ] s), 4, 07 (3H, s), 4.06 (3H, s). NMR DMSO d6 8 7.26 [(LH, ] s), 6. 68 (lH, s), 3.82 (3H, s), 3.78 (3H, s).
An intermediate in the preparation of potential inhibitors of epidermal growth factor receptor kinases. An intermediate in the preparation of Terazosin (T105000).
Computed Properties
Molecular Weight:259.09
XLogP3:3.4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:257.9962829
Monoisotopic Mass:257.9962829
Topological Polar Surface Area:44.2
Heavy Atom Count:16
Complexity:245
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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2,4-Dichloro-6,7-dimethoxyquinazoline
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