3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine
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![3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/889124ffc2ad42009e84da8e969e94f5.png "3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine")
3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine
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CAS No:
111669-25-1
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Formula:
C14H22N4O2
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Chemical Name:
3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine
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Synonyms:
1-(TERT-BUTYLOXYCARBONYL)-4-(3-AMINOPYRIDIN-2-YL)PIPERAZINE;3-AMINO-2-[4-BUTOXYCARBONYL(PIPERAZINO)]PYRIDINE;BUTTPARK 46\04-67;tert-butyl 4-(3-aminopyridin-2-yl)piperazine-1-carboxylate;3-Amino-2-[4-tert-butoxycarbonyl(piperazino)]pyridine ,97%;3-Amino-2-[4-tert-butoxycarbonyl(piperazino)]pyridine;1-Boc-4-(3-aMinopyridin-2-yl)piperazine;butyl 4-(3-aminopyridin-2-yl)piperazine-1-carboxylate
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CAS No:
3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine Basic Attributes
278.35
278.174286
DTXSID00373347
29339900
Characteristics
71.69000
2.30500
1.182±0.06 g/cm3(Predicted)
448.8±45.0 °C(Predicted)
233.7±28.7 °C
1.570
3E-08mmHg at 25°C
3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine Use and Manufacturing
A mixture of tert-butyl 4-(3-nitropyridin-2-yl)piperazine-l -carboxylate 5 (350 mg, 1.14 mmol), Pd/C (60.4 mg, 10percent, 0.0568 mmol) and MeOH (6 ml) was subjected to the hydrogenation condition with hydrogen balloon at room temperature. After stirring for 2 h, the resulting solution was filtered through celite. The resulting organic solution was concentrated under reduced pressure and purified by silica gel column chromatography (Hexane/EtOAc/CHExample 18.1: 4-(3-Ammo-pyridin-2-yl)-piperazine-l-carboxylic acid tert-butyl ester. A mixture of 4-(3-nitro-pyridin-2-yl)-piperazine-l-carboxylic acid tert-tmtyl ester (4.0 g, 12, 97 mmol), palladium (on activated carbon, 500 mg) and ethanol (150 mL) was shaken under 20 psi of hydrogen for 2 hours. The reaction mixture was filtered through Diatomaceous earth and concentrated to give 4-(3-amino-pyridin-2-yl)-piperazine-l- carboxylic acid tert-butyl ester (2.5 g, 69 percent). GC/MS m/z 278, 205, 134, 148, 109, 93, 57.
Computed Properties
Molecular Weight:278.35
XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:278.17427596
Monoisotopic Mass:278.17427596
Topological Polar Surface Area:71.7
Heavy Atom Count:20
Complexity:335
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine
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3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine
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