2-BROMO-3-HYDROXY-5-CHLOROPYRIDINE
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2-BROMO-3-HYDROXY-5-CHLOROPYRIDINE
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CAS No:
127561-70-0
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Formula:
C5H3BrClNO
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Chemical Name:
2-BROMO-3-HYDROXY-5-CHLOROPYRIDINE
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Synonyms:
2-Bromo-5-chloropyridin-3-ol;2-Bromo-5-chloro-3-hydroxypyridine;2-bromo-5-chloro-3-pyridinol;3-Pyridinol,2-bromo-5-chloro-;2-BROMO-3-HYDROXY-5-CHLOROPYRIDINE;3-Pyridinol, 2-bromo-5-chloro-;ACMC-20dyle;PubChem5893;SCHEMBL8651532;AMPD00236
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CAS No:
Safety Information
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
2-BROMO-3-HYDROXY-5-CHLOROPYRIDINE Use and Manufacturing
At 0 C, to a solution of 2-bromo-5- chloropyridin-3-ol (0.95 g, 4.56 mmol) in N, N-dimethylformamide (10 mL) was added sodium hydride (180 mg, 7.50 mmol) in portions. The resulting mixture was stirred for 20 min, and then was added by Mel (741 mg, 5.22 mmol) at 0 C. The resulting mixture was stirred for 0.5 h at 0 C, warmed up to room temperature and stirred for 16 h at room temperature. When the reaction was done, it was quenched by the addition of water (50 mL). The resulting mixture was extracted with ethyl acetate (50 mL x 3). The organic phases were combined, washed with brine and dried over Na2S04. The solvent was removed under reduced pressure and the residue was purified by flash chromatography eluting with EtOAc in hexane (0 % to 2 % gradient) to yield 2-bromo-5- chloro-3-methoxypyridine as a white solid (764 mg, 75 %). MS: m/z = 221.8 [M+H]+.Step 2: Into a solution of
Computed Properties
Molecular Weight:208.44
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:206.90865
Monoisotopic Mass:206.90865
Topological Polar Surface Area:33.1
Heavy Atom Count:9
Complexity:103
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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InquiryCAS No.: 127561-70-0Grade: Industrial GradeContent: 99%
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2-BROMO-3-HYDROXY-5-CHLOROPYRIDINE
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