4,6-DIMETHOXYPYRIMIDINE-2-CARBOXYLICACID

To a solution of (4E)-4-[3 -(3-chlorophenyl)prop-2-ynylidene] -3, 3 -dimethyl-piperidine (Compound 4a, 37 mg, 0.14 mmol) and A mixture of CdCl2 (0.1mmol, 18.3mg) and 4, 6-Dimethoxypyrimidine-2-carboxylic acid 17.1 g of 2-ethoxycarbonyl-4, 6-dimethoxypyrimidine are dissolved in 300 ml of ethanol, and 3.4 g of sodium hydroxide in 50 ml of water are added. This solution is stirred for 4 hours at room temperature and refluxed for 1 hour. The mixture is cooled, and most of the ethanol is removed on a rotary evaporator. The residue is taken up in water and extracted using dichloromethane. The aqueous-alkaline phase is acidified to a pH of 2-3 using 6 N hydrochloric acid, and any precipitated product is filtered off with suction. This gives 9.6 g of EXAMPLE 5 Synthesis of 4, 6-dimethoxy-N-butylsulfonylpyrimidine-2-carboxylic amide (Compound No. 6) 3.0 g (16 mmol) of

Molecular Weight:184.15
XLogP3:0.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:184.04840674
Monoisotopic Mass:184.04840674
Topological Polar Surface Area:81.5
Heavy Atom Count:13
Complexity:175
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes