3-Fluoro-4-nitropyridine

The fluoroaromatic compounds resulting from carrying out the process of this invention using the illustrative chloroaromatic compounds (a) through (z) above are set forth below, followed by utilities for such resulting compounds: ... (s) 3-fluoro-4-(trifluoromethyl)pyridine (t) 3-fluoro-4-cyanopyridine (u) 3-fluoro-4-nitropyridine. (v) 2-fluoronitrobenzene ...The fluoroaromatic compounds resulting from carrying out the process of this invention using the illustrative chloroaromatic compounds (a) through (z) above are set forth below, followed by utilities for such resulting compounds: ... (q) 4-fluoro-phthaloyl dichloride (r) 1, 4-difluoroanthracene-9, 10-dione (s) 3-fluoro-4-(trifluoromethyl)pyridine (t) 3-fluoro-4-cyanopyridine (u) 3-fluoro-4-nitropyridine (v) 2-fluoronitrobenzene (w) 2-fluoro-3-chloronitrobenzene (x) 4-fluoronitrobenzene ...The fluoroaromatic compounds resulting from carrying out the process of this invention using the illustrative chloroaromatic compounds (a) through (z) above are set forth below, followed by utilities for such resulting compounds: ... (q) 4-fluoro-phthaloyl dichloride (r) 1, 4-difluoroanthracene-9, 10-dione (s) 3-fluoro-4-(trifluoromethyl)pyridine (t) 3-fluoro-4-cyanopyridine (u) 3-fluoro-4-nitropyridine. (v) 2-fluoronitrobenzene (w) 2-fluoro-3-chloronitrobenzene (x) 4-fluoronitrobenzene ...(0052) Non-radioactive fluorination of 3-bromo-4-nitropyridine (3): 10 muL of 1 M tetrabutylammonium fluoride (TBAF) solution in THF (10 mumol, 0.5 eq.) was added to a solution of 3-bromo-4-nitropyridine (96%, Aurum Pharmatech, LLC) (20 mumol, 1 eq.) in 500 L of anhydrous dimethylsulfoxide (DMSO) in a 2 mL HPLC vial. The reaction was analyzed by HPLC (conditions A). Retention times: 3-bromo-4-nitropyridine (3)=10.83 min, (0052) Non-radioactive fluorination of 3-bromo-4-nitropyridine (3): 10 muL of 1 M tetrabutylammonium fluoride (TBAF) solution in THF (10 mumol, 0.5 eq.) was added to a solution of 3-bromo-4-nitropyridine (96%, Aurum Pharmatech, LLC) (20 mumol, 1 eq.) in 500 L of anhydrous dimethylsulfoxide (DMSO) in a 2 mL HPLC vial. The reaction was analyzed by HPLC (conditions A). Retention times: 3-bromo-4-nitropyridine (3)=10.83 min, A solution of 4-amino-1-naphthalenecarbonitrile (4 g, 23.8 mmol) in 120 ml of DMF was cooled to below 0 C, NaH (1.2 g, 30.5 mmol) was added and stirred at room temperature for 30 min. After cooling to below 0 C,

Molecular Weight:142.09
XLogP3:0.8
Hydrogen Bond Acceptor Count:4
Exact Mass:142.01785550
Monoisotopic Mass:142.01785550
Topological Polar Surface Area:58.7
Heavy Atom Count:10
Complexity:136
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes