2-Morpholinopyrimidin-4-ol

2B) 2-MORPHOLIN-4-VL-PYRIMIDIN-4-OL To the 2-thiomethyluracil (4.0 g, 0.0281 mol) is added morpholine (3.05 G, 0.035 MOL). The mixture is heated to 145°C for 2 hours then cooled to room temperature. The solid is crystallized from ethanol. White needles are collected (2.0 g). Second crop of crystals form approximately 0.50 g (49percent). M+H = 181. 'H NMR (CDC13) ; 612. 1 (bs, 1H), 7.85 (d, 1H), 5.79 (d, 1H), 3.75 (m, 8H).2B) 2-MORPHOLIN-4-VL-PYRIMIDIN-4-OL To the 2-thiomethyluracil (4.0 g, 0.0281 mol) is added morpholine (3.05 G, 0.035 MOL). The mixture is heated to 145°C for 2 hours then cooled to room temperature. The solid is crystallized from ethanol. White needles are collected (2.0 g). Second crop of crystals form approximately 0.50 g (49percent). M+H = 181. 'H NMR (CDC13) ; 612. 1 (bs, 1H), 7.85 (d, 1H), 5.79 (d, 1H), 3.75 (m, 8H).

Molecular Weight:181.19
XLogP3:-1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:181.085126602
Monoisotopic Mass:181.085126602
Topological Polar Surface Area:53.9
Heavy Atom Count:13
Complexity:267
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes