2-Fluoro-3-pyridinemethanamine

Synthesis of 3-Aminometliyl-2-fluoropyridine19 20[0098] A round bottom flask was charged with 0.3g (2.46mM) of 3-cyano-2- fluoropyridine (19), which was then diluted in 2OmL EtOH. The solution was flushed with argon, and then while under a blanket of argon, 60mg of 10percent Pd/C (20percent by weight), was added. The system was then sealed by septum and put under vacuum. A hydrogen balloon was then added, and the reaction was stirred for three hours (followed by TLC). The reaction was then put under vacuum again, then exposed to air, and filtered (keeping catalyst wet). The resulting solution was dried and evaporated to give 0.28g (90percent) of the title compound, 3-aminomethyl-2-fluoropyridine (20).A round bottom flask was charged with 0.3g (2.46mM) of 3-cyano-2- fluoropyridine (19), which was then diluted in 2OmL EtOH. The solution was flushed with argon, and then while under a blanket of argon, 60mg of 10percent Pd/C (20percent by weight), was added. The system was then sealed by septum and put under vacuum. A hydrogen balloon was then added, and the reaction was stirred for three hours (followed by TLC). The reaction was then put under vacuum again, then exposed to air, and filtered (keeping catalyst wet). The resulting solution was dried and evaporated to give 0.28g (90percent) of the title compound, 3-aminomethyl-2-fiuoropyridine (20).Synthesis of 3-Aminometliyl-2-fluoropyridine19 20[0098] A round bottom flask was charged with 0.3g (2.46mM) of 3-cyano-2- fluoropyridine (19), which was then diluted in 2OmL EtOH. The solution was flushed with argon, and then while under a blanket of argon, 60mg of 10% Pd/C (20% by weight), was added. The system was then sealed by septum and put under vacuum. A hydrogen balloon was then added, and the reaction was stirred for three hours (followed by TLC). The reaction was then put under vacuum again, then exposed to air, and filtered (keeping catalyst wet). The resulting solution was dried and evaporated to give 0.28g (90%) of the title compound, 3-aminomethyl-2-fluoropyridine (20).Synthesis of 3-Aminomethyl-2-fluoropyridine A round bottom flask was charged with 0.3 g (2.46 mM) of 3-cyano-2-fluoropyridine (19), which was then diluted in 20 mL EtOH. The solution was flushed with argon, and then while under a blanket of argon, 60 mg of 10% Pd/C (20% by weight), was added. The system was then sealed by septum and put under vacuum. A hydrogen balloon was then added, and the reaction was stirred for three hours (followed by TLC). The reaction was then put under vacuum again, then exposed to air, and filtered (keeping catalyst wet). The resulting solution was dried and evaporated to give 0.28 g (90%) of the title compound, 3-aminomethyl-2-fluoropyridine (20).A round bottom flask was charged with 0.3g (2.46mM) of 3-cyano-2- fluoropyridine (19), which was then diluted in 2OmL EtOH. The solution was flushed with argon, and then while under a blanket of argon, 60mg of 10% Pd/C (20% by weight), was added. The system was then sealed by septum and put under vacuum. A hydrogen balloon was then added, and the reaction was stirred for three hours (followed by TLC). The reaction was then put under vacuum again, then exposed to air, and filtered (keeping catalyst wet). The resulting solution was dried and evaporated to give 0.28g (90%) of the title compound, 3-aminomethyl-2-fiuoropyridine (20).

Molecular Weight:126.13
XLogP3:0.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:126.05932639
Monoisotopic Mass:126.05932639
Topological Polar Surface Area:38.9
Heavy Atom Count:9
Complexity:87.1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes