2-Fluoro-3-pyridinecarboxaldehyde
-
2-Fluoro-3-pyridinecarboxaldehyde
structure -
-
CAS No:
36404-90-7
-
Formula:
C6H4FNO
-
Chemical Name:
2-Fluoro-3-pyridinecarboxaldehyde
-
Synonyms:
3-Pyridinecarboxaldehyde,2-fluoro-;2-Fluoro-3-pyridinecarboxaldehyde;2-Fluoropyridine-3-carboxaldehyde;2-Fluoro-3-formylpyridine;2-Fluoronicotinaldehyde;2-Fluoropyridine-3-carbaldehyde
- Categories:
-
CAS No:
Characteristics
30
0.7
1.250 g/mL at 25 °C
50 °C @ Press: 3 Torr
164 °F
n20/D 1.520
Room temperature.
Safety Information
IRRITANT
3
36/37/38
26
Xn,Xi
Irritant
P261-P305 + P351 + P338
H302-H315-H319-H335
|Warning|H302 (97.56%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 41 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
2-Fluoro-3-pyridinecarboxaldehyde Use and Manufacturing
A solution of (trimethylsilylmethyl) lithium (22 mL, 13.8 weight percent in hexanes) was charged to a 100 mL 3-NECK round-bottom flask and cooled TO-50 °C. A solution of 2-fluoropyridine (2.0 g), THF (25 mL) and DIISOPROPYLAMINE (0.13 mL) was added at less than-50 °C in 1 minute. After 3 hours, 1-formylpiperidine (2.4 g) was added in 1 min at less THAN-50 °C. The mixture was allowed to warm to room temperature and stir overnight. The reaction mixture was quenched with acetic acid (3 mL) and water (7 mL). The aqueous layer was separated and washed with 3x25 mL MTBE. All organic layers were combined, dried over MGS04 and concentrated in vacuo to leave 3.79 g of brown oil. This oil was chromatographed through silica gel, eluting with 15 percent EtOAc in hexanes, to afford 2. 24 g of 92. 4percent pure 2-FLUORO-3-PYRIDINECARBOXALDEHYDE (90percent yield, corrected for assay).
Through fluorine substitution and isoxazolone, naphthyridine for hydrogenolysis and cyclization can be generated.
Computed Properties
Molecular Weight:125.10
XLogP3:0.7
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:125.027691913
Monoisotopic Mass:125.027691913
Topological Polar Surface Area:30
Heavy Atom Count:9
Complexity:107
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 2-Fluoro-3-pyridinecarboxaldehyde
-
![China]()
CN
5 YRS
Business licensedTrader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives
Learn More Other Chemicals
-
(2E)-3-(1-METHYL-1H-PYRROL-2-YL)ACRYLIC ACID
51485-76-8
-
Benadryl N-oxide hydrochloride
13168-00-8
-
6-CHLORO-3-IODO-IMIDAZO[1,2-A]PYRIDINE
885275-59-2
-
(2-Bromophenyl)diphenylphosphine Formula
62336-24-7
-
1-Morpholinocyclopentene Formula
936-52-7
-
4-[2-(Boc-amino)ethoxy]-benzoic acid Formula
168892-66-8
-
3-amino-5-bromopyridine-2-carboxylic acid Structure
870997-85-6
-
2-Amino-6-methylpyridine Structure
1824-81-3
-
What is 3-Bromo-2-methylthiophene
30319-05-2
-
What is THIOPHEN-2-YLMETHYL-PHOSPHONICACIDDIETHYLESTER
2026-42-8
2-Fluoro-3-pyridinecarboxaldehyde
SDSRequest for Quotation