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Dipyrithione

Dipyrithione structure

CAS No:
3696-28-4
Formula:
C10H8N2O2S2
Chemical Name:
Dipyrithione
Synonyms:
Pyridine,2,2′-dithiobis-,1,1′-dioxide;Pyridine,2,2′-dithiodi-,1,1′-dioxide;Bis(2-pyridyl) disulfide di-N-oxide;Dipyrithione;2,2′-Dithiodipyridine 1,1′-dioxide;Bis(2-pyridyl-N-oxide) disulfide;2,2′-Dithiobispyridine 1,1′-dioxide;Bis(N-oxido-2-pyridyl) disulfide;Bis(2-pyridyl 1-oxide) disulfide;2,2′-Dithiobis(pyridine 1-oxide);Bis(2-pyridine-N-oxide)disulfide;2,2′-Dithiobis(pyridine N-oxide);Omadine disulfide;(1-Oxo-2-pyridyl) disulfide;OSY 20;Omadine DS;Di-2-pyridyl disulfide N,N′-dioxide;NSC 677437;2,2′-Dipyridyl disulfide bis-N-oxide;2,2′-Dipyridyl disulfide N,N′-bisoxide;OMDS;NSC 241716;NSC 84740;Pyrion disulfide;Pyrithione disulfide;bispyrithione;Sentex TBS;1-Oxido-2-[(1-oxidopyridin-1-ium-2-yl)disulfanyl]pyridin-1-ium;84617-33-4;90829-79-1;2305748-09-6
Categories:
Water Treatment Chemical > Biocide & Algicide

Description

beige to slightly grey powder and chunks

Dipyrithione is a pyridinium ion.|Dipyrithione is a pyrithione derivate used as bactericide and fungicide. The drug was marketed under the name Crimanex in the form of shampoo for the treatment of dandruff, however it is no longer available on the manufacturer website (Drossa Pharm. It is currently used as a pesticide. Interestingly, dipyrithione has been studied and shown to have cytotoxic and potent broad-spectrum antitumor activity, which suggests a potential basis for an anticancer drug development. Pyrithione derivatives, such as [DB06815] and sodium pyrithione, are widely used as cosmetic preservatives and as anti-dandruff agents in shampoos. It may be combined with other ingredients, such as triclosan to serve as antifungal and antibacterial skin treatments. Dandruff is a common scalp disease affecting >40% of the world's adult population, and may be caused by fungi such as Malassezia globosa and M. restricta.

Dipyrithione Basic Attributes

Molecular Weight：

252.317

Exact Mass：

252.31

EC Number：

223-024-5

UNII：

9L87N86R9A

NSC Number：

677437|241716|84740

DSSTox ID：

DTXSID1041897

HScode：

2933399090

Characteristics

PSA：

101.52000

XLogP3：

3.34300

Appearance：

beige crystalline powder

Density：

1.38 g/cm3

Melting Point：

205 °C

Boiling Point：

582.8ºC at 760 mmHg

Flash Point：

306.2ºC

Refractive Index：

1.681

Safety Information

safety instructions：

S24/25

Precautionary statement(s)：

P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P391, P403+P233, P405, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (98.53%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 101 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Drug Indication：

Scalp dandruff

Pharmacology：

This drug decreases or eliminates dandruff from the scalp, which is caused by various types of fungi,.

Mechanism of Action：

This drug is a fungicidal agent,. Fungicide, also called antimycotic, any toxic substance used to kill or inhibit the growth of fungi.

MeSH Entry Terms：

2,2'-dithio-bis-pyridine-1-oxide magnesium sulfate

Dipyrithione Use and Manufacturing

Uses

Antibacterial; antifungal.

Manufacturing Info：

Pyridine, 2,2'-dithiobis-, 1,1'-dioxide: ACTIVE

Computed Properties

Molecular Weight:252.3
XLogP3:0.6
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:252.00271985
Monoisotopic Mass:252.00271985
Topological Polar Surface Area:102
Heavy Atom Count:16
Complexity:199
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Dipyrithione

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2,2-Dithiobis(pyridine-N-oxide)

CAS No.: 3696-28-4

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BISPYRITHIONE Chemical Grade

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CAS No.: 3696-28-4

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Guide of Dipyrithione

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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