Microcrystalline cellulose
-
Microcrystalline cellulose
structure -
-
CAS No:
9004-34-6
-
Formula:
(C12H20O10)n
-
Chemical Name:
Microcrystalline cellulose
-
Synonyms:
AVICEL PH;AVICEL PH 101(R);AVICEL PH 102;AVICEL PH 105(R);AVICEL(R);''AVICEL(R)'';AVICEL SF;AVIRIN
- Categories:
-
CAS No:
Description
white powder Microcrystalline cellulose and carboxymethylcellulose sodium occurs as a white or off-white odorless and tasteless hygroscopic powder containing 5–22% sodium carboxymethylcellulose. It is a water-dispersible organic hydrocolloid. Microcrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. It is commercially available in different particle sizes and moisture grades that have
Cellulose is an odorless, white powdery fibers. Density: 1.5 g/cm3. The biopolymer composing the cell wall of vegetable tissues. Prepared by treating cotton with an organic solvent to de-wax it and removing pectic acids by extration with a solution of sodium hydroxide. The principal fiber composing the cell wall of vegetable tissues (wood, cotton, flax, grass, etc.). Technical uses depend on the strength and flexibility of its fibers. Insoluble in water. Soluble with chemical degradation in sulfuric acid, and in concentrated solutions of zinc chloride. Soluble in aqueous solutions of cupric ammonium hydroxide (Cu(NH3)4(OH)2).|WetSolid|Odorless, white substance.|Odorless, white substance. [Note: The principal fiber cell wall material of vegetable tissues (wood, cotton, flax, grass, etc.).]
Cellulose is an odorless, white powdery fibers. Density: 1.5 g/cm3. The biopolymer composing the cell wall of vegetable tissues. Prepared by treating cotton with an organic solvent to de-wax it and removing pectic acids by extration with a solution of sodium hydroxide. The principal fiber composing the cell wall of vegetable tissues (wood, cotton, flax, grass, etc.). Technical uses depend on the strength and flexibility of its fibers. Insoluble in water. Soluble with chemical degradation in sulfuric acid, and in concentrated solutions of zinc chloride. Soluble in aqueous solutions of cupric ammonium hydroxide (Cu(NH3)4(OH)2).|A disaccharide consisting of two glucose units in beta (1-4) glycosidic linkage. Obtained from the partial hydrolysis of cellulose.
A natural carbohydrate high polymer (polysaccha- ride) consisting of anhydroglucose units joined by an oxygen linkage to form long molecular chains that are essentially linear. It can be hydrolyzed to glucose. The degree of polymerization is from 1000 for wood pulp to 3500 for cotton fiber, giving a molecular weight from 160,000 to 560,000. Cellulose is a colorless solid, d approximately 1.50, insoluble in water and organic solvents. It will swell in sodium hydroxide solution and is soluble in Schweitzer’s reagent. It is the fundamental con- stituent of all vegetable tissues (wood, grass, cotton, etc.) and the most abundant organic material in the world. Cotton fibers are almost pure cellulose; wood contains approximately 50%. The physical structure of cellulose is unusual in that it is not a single crystal but consists of crystalline areas embedded in amorphous areas. Chemical reagents penetrate the latter more easily than the former. Cel- lulose is virtually odorless and tasteless and is com- bustible, with an ignition point of approximately 450F. In some forms, it is flammable. For example, railroad shipping regulations require a flammable label on such items as burnt fiber, burnt cotton, wet waste paper, and wet textiles. Fires have been known to occur in warehouses in which telephone books were stored. These were undoubtedly due to heat buildup in the paper caused by microbial activity and self-sustaining oxidation.
A nuisance dust. When heated to decomposition it emits acrid smoke and irritating fumes.
Microcrystalline cellulose Basic Attributes
324.28
2.01588
232-674-9
2559
TSCA listed
DTXSID1023233|DTXSID3045984|DTXSID3050492|DTXSID50873004
White or almost white
39129090
Characteristics
190 Ų
4.75
powder
1.5 g/cm3 (20℃)
76-78 °C(Solv: acetone (67-64-1); chloroform (67-66-3))
237.6±35.0 °C at 760 mmHg
164 °C
n20/D 1.504
insoluble
room temp
0 mm Hg (approx) (NIOSH, 2016)|0 mmHg (approx)
LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rabbit > 2000 mg/kg
Odorless
5-7.5 (100g/l, H2O, 20℃)(slurry)
No rapid reaction with air No rapid reaction with water
Alcohols and Polyols
Cellulose microcrystalline is combustible. Incompatible with strong oxidizing agents including bromine pentafluoride, sodium nitrate, fluorine, perchlorates, perchloric acid, sodium chlorate, magnesium perchlorate, F2, zinc permanganate, sodium nitrite, sodium nitrate, sodium peroxide. Nitration with a mixture of nitric and sulfuric acids produces Cellulose microcrystalline nitrates (celluloid pyroxylin, soluble pyroxyline, guncotton) which are flammable or explosive.
232 °C
Combustible Solid
room temp
Safety Information
NONH for all modes of transport
3
Xi
24/25
FJ5950200
Xi
Microcrystalline cellulose and carboxymethylcellulose sodium is hygroscopic and should not be exposed to moisture. It is stable over a pH range of 3.5–11. Store in a cool, dry place. Avoid exposure to excessive heat.
Stable. Combustible. Incompatible with strong oxidizing agents.
37
Microcrystalline cellulose is incompatible with strong oxidizing agents.
Not Classified
Skin: No recommendation is made specifying the need for personal protective equipment for the body. Eyes: No recommendation is made specifying the need for eye protection. Wash skin: No recommendation is made specifying the need for washing the substance from the skin (either immediately or at the end of the work shift). Remove: No recommendation is made specifying the need for removing clothing that becomes wet or contaminated. Change: No recommendation is made specifying the need for the worker to change clothing after the work shift. (NIOSH, 2016)|(See protection codes)
Toxicity
ACGIH:TLV-TWA 10 mg/m3OSHA:PEL-TWA 15 mg/m3 (total dust),5 mg/m3 (respirable fraction)NIOSH:REL-TWA 10 mg/m3 (total dust),5 mg/m3 (respirable fraction)
Drug Information
Cellulose is inert and is classified as a nuisance dust.It has little, if any, adverse effect on the lung, and there are no reports of organic disease or toxic effect. The health effects attributed to wood, cotton, flax, jute, and hemp are not attributable to their cellulose content but rather to the presence of other substances.Cellulose fibers were found in the blood and urine of human volunteers fed dyed cellulose; there were no ill effects.
Eye: If this chemical contacts the eyes, immediately wash the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Contact lenses should not be worn when working with this chemical. Skin: If this chemical contacts the skin, wash the contaminated skin with soap and water. Breathing: If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. Other measures are usually unnecessary. (NIOSH, 2016)|(See procedures)
4 O beta D Glucopyranosyl D glucopyranose
inhalation, skin and/or eye contact
irritation eyes, skin, mucous membrane
Eyes, skin, respiratory system
Microcrystalline cellulose Use and Manufacturing
1. High purity cellulose powders for partition chromatography.
2. ACCEL-101 is most widely used for direct compression tableting and wet granulation.ACCEL-102 has similar compression properties to ACCEL-101. However, it has larger particle size and therefore, may be of value in improving the flow if fine powders.ACCEL
Adhesives and sealant chemicals
High purity cellulose powders for partition chromatography.
cellulose is a thickener and an emulsifier. It is obtained from plants. cellulose (microcrystalline) is used as an emulsifier in cosmetic creams. It is the chief constituent of plant fiber.
Wood contains 50–70% cellulose; cotton and other textile fibers of plant origin contain 65–95%; rayon is prepared by dissolving natural cellulose and then precipitating it from solution, with some loss of crystallinity. Cellulose is made into cellophane film and is used to form fibers, resins, coatings and gums.
Microcrystalline cellulose and carboxymethylcellulose sodium is a spray- or bulk-dried blend of microcrystalline cellulose and sodium carboxymethylcellulose. It is prepared by the chemical depolymerization of highly purified wood pulp. The original crystalline areas of the pulp fibers are combined with sodium carboxymethylcellulose, which serves as a protective colloid and also facilitates dispersion of the product; it is then either spray- or bulk-dried.
Microcrystalline cellulose is manufactured by controlled hydrolysis with dilute mineral acid solutions of α-cellulose, obtained as a pulp from fibrous plant materials. Following hydrolysis, the hydrocellulose is purified by filtration and the aqueous slurry is spraydried to form dry, porous particles of a broad size distribution.
.alpha.-D-Glucopyranose, 4-O-.beta.-D-galactopyranosyl-: ACTIVE|D-Glucose, 4-O-.beta.-D-glucopyranosyl-: ACTIVE|.beta.-D-Glucopyranose, 4-O-.beta.-D-galactopyranosyl-: ACTIVE|D-Glucose, 4-O-.beta.-D-galactopyranosyl-: ACTIVE|Primary metal manufacturing|D-Glucose, 4-O-.alpha.-D-glucopyranosyl-: ACTIVE|Cellulose: ACTIVE|XU - indicates a substance exempt from reporting under the Chemical Data Reporting Rule, (40 CFR 711).
EPA Safer Chemical Functional Use Classes -> Processing Aids and Additives|Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern|Cosmetics -> Absorbent; Bulking; Masking; Moisturising; Opacifying; Skin conditioning; Viscosity controlling
Food Additives -> ANTICAKING_AGENT; EMULSIFIER; STABILIZER;|Food Additives -> ANTICAKING_AGENT; EMULSIFIER; TEXTURIZER; THICKENER;
Computed Properties
Molecular Weight:342.30
XLogP3:-4.7
Hydrogen Bond Donor Count:8
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:4
Exact Mass:342.11621151
Monoisotopic Mass:342.11621151
Topological Polar Surface Area:190
Heavy Atom Count:23
Complexity:382
Undefined Atom Stereocenter Count:10
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
The specific pharmacological effect is not clear from the above information
Registered Holders
-
Luogaite Health Pharmaceuticals (Shanghai) Co., Ltd.
Active
China
-
Ruisheng Pharmaceutical (Henan) Co., Ltd.
Active
China
-
ZHUHAI TOPCHAIN PHARMACEUTICAL CO LTD
Active
United States
Recommended Suppliers of Microcrystalline cellulose
-
CN
5 YRS
Business licensed Certified factoryManufactory Supplier of BCAA,Ascorbic Acid (Vitamin C),Monk Fruit Extract,Acai Berry Extract,Taurine,AAKG,Glycine,Stevia,Creatine Monohydrate,Allulose,ErythritolInquiryCAS No.: 9004-34-6Grade: Food Grade -
InquiryUnit Price: $3100-3400 /MT FOBCAS No.: 9004-34-6Grade: Food GradeContent: 99%
-
CN
10 YRS
Business licensed Certified factoryManufactory Supplier of Chloroprene rubber(CR),Thermoplastic Polyerethane Elastomer(TPU),Benzophenone(BP),Tetrabutylurea(TBU),Polyphenylene sulfide(PPS),Polyanionic Cellulose (PAC),Carboxymethyl cellulose(CMC) -
CN
5 YRS
Business licensedDistributor Supplier of Snow Melting Agents,Sodium hexametaphosphate,Caustic Soda,Butyl acrylate,Sodium hydroxide,Sulfur dioxide,Glyphosate,Citric Acid,Ammonium dihydrogen phosphate,Sodium sulphate,Phosphorus pentoxide,Sodium bicarbonate,Phosphoric acid,Potassium hydroxide,Titanium dioxideInquiryCAS No.: 9004-34-6Grade: Food GradeContent: 99% -
CN
4 YRS
Business licensedTrader Supplier of Semaglutide,APIs,Alpha GPC,Liraglutide,Herbal Extract,Nervonic Acid,Coenzyme Q10,Herbal extracts,Guaiazulene,CDMO services,Pharmaceutical intermediates,Healthcare & Food Supplements,NAD,L-theanine,Glyoxylic acid,L-Glutathione reduced,Spermidine,Diosmin,Gliclazide,Cosmetic Raw Materials,Citicoline Sodium,Nervonic Acid
Learn More Other Chemicals
-
BENZYL DEAE CELLULOSE COARSE MESH
56508-80-6
-
CELLULOSE TRIBENZOATE
37361-36-7
-
Sodium cellulose sulfate
9005-22-5
-
Hydroxypropyl methyl cellulose phthalate Formula
9050-31-1
-
Carboxymethyl Cellulose Formula
9000-11-7
-
Hydroxybutyl methyl cellulose Formula
9041-56-9
-
Cellulose acetobutyrate Structure
9004-36-8
-
Cyanoethyl cellulose Structure
9004-41-5
-
What is Cellulose diacetate
9035-69-2
-
What is Ethyl hydroxyethyl cellulose
9004-58-4
Request for Quotation