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2-FORMYL-4-PICOLINE

2-FORMYL-4-PICOLINE structure

CAS No:
53547-60-7
Formula:
C7H7NO
Chemical Name:
2-FORMYL-4-PICOLINE
Synonyms:
2-FORMYL-4-PICOLINE;4-METHYLPYRIDINE-2-CARBOXALDEHYDE;4-Methylpyridine-2-carboxaldehyde 95%;2-FORMYL-4-METHYLPYRIDINE;4-Methylpicolinaldehyde;4-Methylpyridine-2-carbaldehyde;2-Formyl-4-methylpyridine, 4-Methylpicolinaldehyde;Picolinaldehyde, 4-methyl-
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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2-FORMYL-4-PICOLINE Basic Attributes

Molecular Weight：

121.14

Exact Mass：

121.052765

HScode：

2933399090

Characteristics

PSA：

XLogP3：

0.7

Density：

1.082 g/mL at25 °C

Boiling Point：

208.8°C at 760 mmHg

Flash Point：

85℃

Refractive Index：

n20/D1.531

Safety Information

wgk germany：

hazard class code：

Marks：

Hazard note：

Harmful

Precautionary statement(s)：

P305 + P351 + P338

Hazard Statements：

H302-H319

2-FORMYL-4-PICOLINE Use and Manufacturing

4-Methyl-pyridine-2-carbaldehyde (433 mg, 71. [5percent)] was obtained from 0.25 M 4-methyl- [2-PYRIDINYLMAGNESIUM] bromide of THF solution (20 mL, 5 mmol) with DMF (0.773 [ML, ] [10 MMOL)] at room temperature under argon.Reference Example 55 (b) In a manner similar to that described for the preparation of 4-cyano-2-pyridinecarboxaldehyde, 2-hydroxymethyl-4-methylpyridine (2.60 g, 21.14 mmol) provided 2.0 g (78%) of the 4-methyl-2-pyridinecarboxaldehyde. TLC (silica gel GF): Rf =0.23 acetone-methylene-hexane (0.5:1.5:8.0). 1 H NMR (CDCl3, TMS):delta 10.09 (s, 1H), 8.67 (d, 1H, J=4.93 Hz), 7.81 (s, 1H):delta 7.38 (d, 1H, J=3.78 Hz), 2.48 (s, 3H).General procedure: The equimolar amount 6-(1H-indol-3-yl)-4, 5?-bipyrimidine-2-amine and substituted aldehydes were mixed in a round bottom flask containing 50 mL of ethanol, some droplets of glacial acetic acid were added to the mixture, and it was set on refluxing for 18 h. Solid product was observed on the completion of reaction that was filtered and dried under vacuum and recrystallized using proper solvent [50].

Computed Properties

Molecular Weight:121.14
XLogP3:0.7
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:121.052763847
Monoisotopic Mass:121.052763847
Topological Polar Surface Area:30
Heavy Atom Count:9
Complexity:103
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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4-Methylpyridine-2-carbaldehyde

CAS No.: 53547-60-7

Content: 99.00%

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