5-Chloro-2-methylpyrimidine
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5-Chloro-2-methylpyrimidine
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CAS No:
54198-89-9
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Formula:
C5H5ClN2
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Chemical Name:
5-Chloro-2-methylpyrimidine
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Synonyms:
5-chloro-2-methylpyrimidine;PYRIMIDINE, 5-CHLORO-2-METHYL-;NSC165372;2-methyl-5-chloropyrimidine;SCHEMBL1045564;CTK8B6614;DTXSID80304311;CS-D1091;ZINC1644846;ANW-53759
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CAS No:
5-Chloro-2-methylpyrimidine Use and Manufacturing
To a solution of 2, 5-dichloropyrimidine (5 mmol) and Ni(dppf)Cl2 (0.25 mmol) in ether (30 mL) was added MeMgBr (6 mmol, 1M in THF) dropwise under nitrogen atmosphere and the resulting mixture was refluxed overnight. After cooling to rt, water (20 mL) was added and the mixture was extracted with ether (3 x 35 mL). The combined organic layers were washed with brine and dried over anhydrous Na2S04. After filtration and concentration, the crude product was purified by column chromatography to give the title compound.
Computed Properties
Molecular Weight:128.56
XLogP3:1.2
Hydrogen Bond Acceptor Count:2
Exact Mass:128.0141259
Monoisotopic Mass:128.0141259
Topological Polar Surface Area:25.8
Heavy Atom Count:8
Complexity:68.8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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