2-Chloro-5-ethyl-pyridine

2-chloro-5-vinylpyridine (1g, 7.2mmol) is dissolved in 20 ml of methanol; the resulting solution is passed through hydrogen for 2 minutes, after that added 1, 5-cyclooctadiene (pyridine) (tricyclohexyl-phosphine) iridium (I) hexafluorophosphate catalyst (0.1g), subsequently, the mixture is reacted in a hydrogenation reactor (1atm hydrogen) for 2 hours. The reaction solution is concentrated by filtration through diatomite, and then added 10 ml of dichloromethane and 10 ml of water. The organic phase is separated and dried over anhydrous magnesium sulfate, filtration, steaming and concentrating and then obtained 2-chloro-5-ethylpyridine 0.84g, light yellow liquid, yield 83percent.

2-Chloro-5-ethylpyridine is a disubstituted pyridine used in the preparation of biologically active compounds such as potential vanilloid receptor-1 antagonists.

Molecular Weight:141.60
XLogP3:2.6
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:141.0345270
Monoisotopic Mass:141.0345270
Topological Polar Surface Area:12.9
Heavy Atom Count:9
Complexity:85
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes