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Rivastatin

Rivastatin structure

CAS No:
143201-11-0
Formula:
C26H34FNO5.Na
Chemical Name:
Rivastatin
Synonyms:
6-Heptenoic acid,7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-,sodium salt (1:1),(3R,5S,6E)-;6-Heptenoic acid,7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-,monosodium salt,[S-[R*,S*-(E)]]-;6-Heptenoic acid,7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-,monosodium salt,(3R,5S,6E)-;Rivastatin;BAY-w 6228;Cerivastatin sodium;Baycol;Lipobay
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

SolidChEBI: The sodium salt of cerivastatin. Formerly used to lower cholesterol and prevent cardiovascular disease, it was withdrawn from the market worldwide in 2001 following reports of a severe form of muscle toxicity.Lipobay was launched in Denmark, Germany and the UK for treatment of primary hypercholesteremia types Ⅱa and Ⅱb. It is available through a nine step synthesis beginning with the Hantsch reaction of ethyl 3-amino-4-methylpent-2-enoate and 4-(ethoxycarbonyl)-5-(4-fluorophenyl)

Rivastatin Basic Attributes

Molecular Weight：

459.55

Exact Mass：

459.24200

Characteristics

PSA：

99.88000

XLogP3：

4.88070

Appearance：

white to tan

Melting Point：

197-199°C

Boiling Point：

646.3ºC at 760 mmHg

Flash Point：

344.7ºC

Water Solubility：

H2O: ≥5mg/mL

Storage Conditions：

Hygroscopic, Store under Inert atmosphere-20°C Freezer

Vapor Pressure：

1.03X10-16 mm Hg at 25 °C (est)

Specific rotation：

D20 +24.1° (c = 1 in ethanol)

Safety Information

wgk germany：

Rivastatin Use and Manufacturing

A competitive inhibitor of HMG-CoA reductase.