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Naltrexone

Naltrexone structure

CAS No:
16590-41-3
Formula:
C20H23NO4
Chemical Name:
Naltrexone
Synonyms:
Morphinan-6-one,17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-,(5α)-;Morphinan-6-one,17-(cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxy-;(5α)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one;1-N-Cyclopropylmethyl-7,8-dihydro-14-hydroxynormorphinone;N-Cyclopropylmethylnoroxymorphone;Naltrexone;EN 1639;Depotrex;Nemexin;UM 792;Naltrel;Trexonil;Vivitrex;Vivitrol;(-)-Naltrexone
Categories:
Active Pharmaceutical Ingredients > Specialty Drugs

Description

ChEBI: An organic heteropentacyclic compound that is naloxone substituted in which the allyl group attached to the nitrogen is replaced by a cyclopropylmethyl group. A mu-opioid receptor antagonist, it is used to treat alcohol dependence.Naltrexone is a pure opioid antagonist at allopioid receptor subtypes with the highest affinity for theμ-receptor. Naltrexone is orally bioavailable and blocksthe effects of opiate agonists for approximately 24 hoursafter a single dose of 50 mg. It produces no

Naltrexone Basic Attributes

Molecular Weight：

341.4

Exact Mass：

341.40

EC Number：

240-649-9

HScode：

2939190000

Characteristics

PSA：

XLogP3：

0.7

Appearance：

Solid

Density：

1.2064 (rough estimate)

Melting Point：

168-170 °C

Boiling Point：

477.03°C (rough estimate)

Flash Point：

9℃

Refractive Index：

1.5614 (estimate)

Water Solubility：

3.07e+00 g/L

Storage Conditions：

2-8°C

Vapor Pressure：

1.30X10-11 mm Hg at 25 deg C (est)

Toxicity：

Subcutaneous-mouse LD50: 551 mg/kg

Flammability characteristics：

Combustible; Fire breaks down toxic nitrogen oxide fumes

Safety Information

Transport codes：

UN1230 - class 3 - PG 2 - Methanol, solution

wgk germany：

hazard class code：

11-23/24/25-39/23/24/25

safety instructions：

16-36/37-45

Marks：

F,T

Storage features：

Treasury is ventilated at low temperature and dry; stored and transported separately from oxidants and food

Stability/Shelf Life：

Stable under recommended storage conditions. /Naltrexone hydrochloride/

Precautionary statement(s)：

P210-P260-P280-P301 + P310-P311

Hazard Statements：

H225-H301 + H311 + H331-H370

Toxicity

Toxicity class：

highly toxic

Naltrexone Use and Manufacturing

Labeled Naltrexone, intended for use as an internal standard for the quantification of Naltrexone by GC- or LC-mass spectrometry.

Drug Function and Efficacy

Naltrexone is an opioid receptor antagonist that can significantly weaken or completely block opioid receptors, and even reverse the effects of intravenous opioids. It can relieve the physical dependence on opioids and enable opioid addicts who have quit opioids to maintain a normal life. This product is effective when taken orally, and its effects last for a long time. This product does not produce physical or mental dependence.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Naltrexone Hydrochloride Tablets
Ingredients	The main ingredients of this product are chemical names: 17-cyclopropylmethyl-4- and b-epoxy-3,14-dihydroxymorphan-6-one. Structural formula: Molecular formula: C20H23NO4 Molecular weight: 341.14
Indication	This product may interfere with the therapeutic effects of opioid-containing drugs. Anyone using opioid analgesics should avoid using them simultaneously with such drugs.
Specifications	5mg

Naltrexone Hydrochloride Tablets
Ingredients	The main ingredients of this product are chemical names: 17-cyclopropylmethyl-4- and b-epoxy-3,14-dihydroxymorphan-6-one. Structural formula: Molecular formula: C20H23NO4 Molecular weight: 341.14
Indication	This product may interfere with the therapeutic effects of opioid-containing drugs. Anyone using opioid analgesics should avoid using them simultaneously with such drugs.
Specifications	50mg
Manufacturer	Beijing Wellso Pharmaceutical Co., Ltd.

Registered Holders

SANECA PHARMACEUTICALS AS

United States
Active
SpecGx LLC

United States
Active
SIEGFRIED AG

France
Active

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