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Naftidrofuryl

Naftidrofuryl structure

CAS No:
31329-57-4
Formula:
C24H33NO3
Chemical Name:
Naftidrofuryl
Synonyms:
2-Furanpropanoic acid,tetrahydro-α-(1-naphthalenylmethyl)-,2-(diethylamino)ethyl ester;2-Furanpropionic acid,tetrahydro-α-(1-naphthylmethyl)-,2-(diethylamino)ethyl ester;2-(Diethylamino)ethyl tetrahydro-α-(1-naphthylmethyl)-2-furanpropionate ester;Naftidrofuryl;N-Diethylamino ethyl β-(1-naphthol)-β-(2-tetrahydrofuryl)isobutyrate oxolate salt;Nafronyl;Naphtidrofuryl;LS 84;Gevatran;Tridus;2-(Diethylamino)ethyl 3-(naphthalen-1-yl)-2-((tetrahydrofuran-2-yl)methyl)propanoate;2-(Diethylamino)ethyl 3-(naphthalen-1-yl)-2-(tetrahydrofuran-2-ylmethyl)propanoate;860-36-6
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

2-(1-naphthalenylmethyl)-3-(2-oxolanyl)propanoic acid 2-(diethylamino)ethyl ester is a member of naphthalenes.|A drug used in the management of peripheral and cerebral vascular disorders. It is claimed to enhance cellular oxidative capacity and to be a spasmolytic. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1310) It may also be an antagonist at 5HT-2 serotonin receptors.

Naftidrofuryl Basic Attributes

Molecular Weight：

383.52

Exact Mass：

383.52

EC Number：

250-572-2

UNII：

42H8PQ0NMJ

DSSTox ID：

DTXSID3023344

ATC Code：

C04AX21|C - Cardiovascular system

HScode：

2932190090

Characteristics

PSA：

38.8

XLogP3：

4.45260

Density：

d431 1.0465

Melting Point：

80-83°C

Boiling Point：

190 °C

Flash Point：

267.3ºC

Refractive Index：

nD29 1.5513

Toxicity：

LD50 in mice (mg/kg): 365 orally (Bessin)

Safety Information

Marks：

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 2 companies from 1 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)|Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS. (See all compounds classified as Serotonin Antagonists.)

MeSH Entry Terms：

Artocoron

Naftidrofuryl Use and Manufacturing

Uses

Nafronyl is a selective inhibitor of serotonin receptors

Use Classification：

Pharmaceuticals

Computed Properties

Molecular Weight:383.5
XLogP3:4.8
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:11
Exact Mass:383.24604391
Monoisotopic Mass:383.24604391
Topological Polar Surface Area:38.8
Heavy Atom Count:28
Complexity:465
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Benzyl chloride

Dimethylformamide

Dimethyl sulfate

Furfural

Recommended Suppliers of Naftidrofuryl

Hefei Heyu Chemical New Materials Co., Ltd Contact Supplier

CN
4 YRS

Business licensed

Trader Supplier of 13-Dimethyladamantane,1-Bromo-35-dimethyladamantane,perhydroacenaphthylene,4-[1,1-bis(4-hydroxyphenyl)ethyl]phenol,CYCLOBUTANE-1,2-DICARBOXYLIC ACID DIMETHYL ESTER, TRANS

Naftidrofuryl 31329-57-4

CAS No.: 31329-57-4

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