 Home > Encyclopedia > Metaraminol bitartrate

Metaraminol bitartrate

Metaraminol bitartrate structure

CAS No:
33402-03-8
Formula:
C9H13NO2.C4H6O6
Chemical Name:
Metaraminol bitartrate
Synonyms:
Benzenemethanol,α-[(1S)-1-aminoethyl]-3-hydroxy-,(αR)-,(2R,3R)-2,3-dihydroxybutanedioate (1:1);Benzyl alcohol,α-(1-aminoethyl)-m-hydroxy-,(-)-,tartrate (1:1) (salt);Benzenemethanol,α-(1-aminoethyl)-3-hydroxy-,[R-(R*,S*)]-,[R-(R*,R*)]-2,3-dihydroxybutanedioate (1:1) (salt);Benzenemethanol,α-[(1S)-1-aminoethyl]-3-hydroxy-,(αR)-,(2R,3R)-2,3-dihydroxybutanedioate (1:1) (salt);Aramine;Metaraminol bitartrate;(-)-Metaraminol bitartrate;Metaraminol tartrate;Metaradrine bitartrate;Aramine (sympathomimetic);Metaraminol hydrogen tartrate;Pressorol;Icoral B;17171-57-2;36699-41-9
Categories:
Organic Chemistry > Amides

Description

Colourless solid

A sympathomimetic agent that acts predominantly at alpha-1 adrenergic receptors. It has been used primarily as a vasoconstrictor in the treatment of HYPOTENSION.

Metaraminol bitartrate Basic Attributes

Molecular Weight：

317.29

Exact Mass：

317.111053

EC Number：

251-502-3

DSSTox ID：

DTXSID1045580

HScode：

2922509090

Characteristics

PSA：

182

Melting Point：

176-177 °C

Boiling Point：

357.9ºC at 760 mmHg

Flash Point：

170.3ºC

Safety Information

Transport codes：

UN 2811 6.1/PG 3

wgk germany：

hazard class code：

23/24/25

safety instructions：

26-28-36/37/39-45

RTECS Number：

DN5160000

Marks：

Precautionary statement(s)：

P261-P280-P301 + P310-P311

Hazard Statements：

H301 + H311 + H331

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P311, P312, P321, P322, P330, P361, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Compounds that bind to and activate ADRENERGIC ALPHA-1 RECEPTORS. (See all compounds classified as Adrenergic alpha-1 Receptor Agonists.)|Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)|Drugs used to cause constriction of the blood vessels. (See all compounds classified as Vasoconstrictor Agents.)

MeSH Entry Terms：

Aramine

Metaraminol bitartrate Use and Manufacturing

Uses

antiinfective

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:317.29
Hydrogen Bond Donor Count:7
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:5
Exact Mass:317.11106656
Monoisotopic Mass:317.11106656
Topological Polar Surface Area:182
Heavy Atom Count:22
Complexity:274
Defined Atom Stereocenter Count:2
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product mainly acts on alpha receptors, directly stimulating alpha receptors. Its effect is weaker than that of norepinephrine but more persistent. Its cardiovascular effect is similar to that of norepinephrine. It can constrict blood vessels, continuously increase systolic and diastolic blood pressure, and enhance myocardial contractility. The cardiac output of normal people does not change much, but it can increase the cardiac output of patients with shock. The excitement of heart rate is not very significant, rarely causes arrhythmia, and has no central nervous system excitation effect. Because its pressor effect is reliable and lasts for a long time, it rarely causes reactions such as palpitations or decreased urine volume. When administered continuously, because this product indirectly replaces the transmitter in the adrenergic nerve vesicles, it can reduce the transmitter and weaken the intrinsic effect. Therefore, it should not be stopped suddenly to avoid rebound hypotension.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Metahydroxylamine bitartrate injection
Ingredients	The chemical name of this product is: (-)-alpha;(1-aminoethyl)-3-hydroxybenzyl alcohol bitartrate. Molecular formula: C9H13NO2C4H6O6 Molecular weight: 317.29.
Indication	1. When used in combination with cyclopropane, halothane or other halogenated hydroxyl anesthetics, it is easy to cause arrhythmia. 2. When used in combination with monoamine oxidase inhibitors, the pressor effect is enhanced, causing severe hypertension. 3. When used in combination with digitalis or other adrenergic drugs, it can cause ectopic rhythm. 4. It is not suitable to be infused together with alkaline drugs, because it can cause the decomposition of this product.
Specifications	Based on C9H13NO2 1ml:10mg
Manufacturer	Beijing Yongkang Pharmaceutical Co., Ltd.

Meta-hydroxylamine bitartrate
Manufacturer	Beijing Taiyang Pharmaceutical Industry Co., Ltd.

Metahydroxylamine bitartrate injection
Ingredients	The chemical name of this product is: (-)-alpha; (1-aminoethyl)-3-hydroxybenzyl alcohol bitartrate. Molecular formula: C9H13NO2C4H6O6 Molecular weight: 317.29
Indication	1. When used in combination with cyclopropane, halothane or other halogenated hydroxy anesthetics, it may easily cause arrhythmia; 2. When used in combination with monoamine oxidase inhibitors, the pressor effect is enhanced, causing severe hypertension; 3. When used in combination with digitalis or other adrenergic drugs, it may cause ectopic heart rhythm; 4. It should not be co-injected with alkaline drugs because it may cause the decomposition of this product.
Specifications	1ml: 10mg meta-hydroxylamine (equivalent to 19mg meta-hydroxylamine bitartrate)

See More Related Drugs

Registered Holders

Beijing Yuantong Kangbai Pharmaceutical Co., Ltd.

China
Active
Shanghai Neutrump Pharmatech Co., Ltd.

China
Active
BrightGene Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

Recommended Suppliers of Metaraminol bitartrate

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Metaraminol bitartrate

CAS No.: 33402-03-8

Content: 99.00%

Inquiry
Shandong Airuike Chemical Co., Ltd. Contact Supplier

CN
2 YRS

Business licensed

Trader Supplier of api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals,CATALYST AND AUXILIARY,FLAVORS AND FRAGRANCES,Chemical Pesticides,ADDITIVE

metaraminol bitartrate33402-03-8

CAS No.: 33402-03-8

Grade: Pharmaceutical Grade

Content: 99%

Inquiry