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Budralazine

Budralazine structure

CAS No:
36798-79-5
Formula:
C14H16N4
Chemical Name:
Budralazine
Synonyms:
3-Penten-2-one,4-methyl-,2-(1-phthalazinyl)hydrazone;1(2H)-Phthalazinone,(1,3-dimethyl-2-butenylidene)hydrazone;DJ 1461;Budralazine;Buterazine
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

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Budralazine Basic Attributes

Molecular Weight：

240.31

Exact Mass：

240.30

EC Number：

204-319-8

UNII：

S0177QHV2B

Characteristics

PSA：

53.40000

XLogP3：

2.80570

Density：

1.1g/cm3

Melting Point：

132-133 °C

Boiling Point：

443.5ºC at 760mmHg

Flash Point：

222ºC

Refractive Index：

1.593

Toxicity：

LD50 in mice, rats (mg/kg): 1820, 620 orally; 4020, 3570 i.p. (Onodera)

Safety Information

wgk germany：

hazard class code：

safety instructions：

22-24/25

RTECS Number：

TH9185000

Marks：

Drug Information

MeSH：

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

MeSH Entry Terms：

1-(2-(1,3-dimethyl-2-butenylidene)hydrazino)phthalazine

Budralazine Use and Manufacturing

Budralazine a new antihypertensive agent. Budralazine is a direct-acting vasodilator.

Computed Properties

Molecular Weight:240.30
XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:240.137496527
Monoisotopic Mass:240.137496527
Topological Polar Surface Area:50.2
Heavy Atom Count:18
Complexity:331
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes