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Cibenzoline

Cibenzoline structure

CAS No:
53267-01-9
Formula:
C18H18N2
Chemical Name:
Cibenzoline
Synonyms:
1H-Imidazole,2-(2,2-diphenylcyclopropyl)-4,5-dihydro-;2-(2,2-Diphenylcyclopropyl)-4,5-dihydro-1H-imidazole;Cibenzoline;Cifenline;(RS)-Cibenzoline;(±)-Cibenzoline;UP 33-901;Ro 22-7796;125876-54-2
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

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Description

Cibenzoline is a diarylmethane.

Cibenzoline Basic Attributes

Molecular Weight：

262.35

Exact Mass：

262.35

EC Number：

258-453-7

DSSTox ID：

DTXSID9022819

ATC Code：

C - Cardiovascular system

HScode：

2933290090

Characteristics

PSA：

24.4

XLogP3：

2.75870

Density：

1.17 g/cm3

Melting Point：

103.5 °C

Boiling Point：

449.2ºC

Flash Point：

225.5ºC

Refractive Index：

1.655

Toxicity：

LD100 in rats (mg/kg): 64 i.v. (Cognaco)

Safety Information

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P280, P301+P312, P302+P352, P321, P330, P332+P313, P362, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH：

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

MeSH Entry Terms：

2-(2,2-diphenylcyclopropyl)-2-imidazoline

Cibenzoline Use and Manufacturing

The first class of anti-arrhythmic drugs produces anti-arrhythmic effects by inhibiting Na+ influx of cardiomyocytes, and can extend the duration of action potentials, and can also reduce Ca2+ influx. It has the characteristics of the third and fourth types. It is used to reduce and prevent extraventricular and supraventricular contractions, prevent the onset of paroxysmal supraventricular tachycardia, and maintain sinus rhythm after recovery of atrial fibrillation and flutter.

Computed Properties

Molecular Weight:262.3
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:3
Exact Mass:262.146998583
Monoisotopic Mass:262.146998583
Topological Polar Surface Area:24.4
Heavy Atom Count:20
Complexity:357
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Acrylonitrile