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Pinacidil

Pinacidil structure

CAS No:
60560-33-0
Formula:
C13H19N5
Chemical Name:
Pinacidil
Synonyms:
Guanidine,N-cyano-N′-4-pyridinyl-N′′-(1,2,2-trimethylpropyl)-;N-Cyano-N′-4-pyridinyl-N′′-(1,2,2-trimethylpropyl)guanidine;P 1134;Pinacidil;S 1230;(±)-Pinacidil;(R,S)-Pinacidil;Pindac;1-(3,3-Dimethylbutan-2-yl)-2-cyano-3-(pyridin-4-yl)guanidine;113563-69-2
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

1-cyano-2-(3,3-dimethylbutan-2-yl)-3-pyridin-4-ylguanidine is a member of pyridines.|Pinacidil is a cyanoguanidine drug that acts by opening ATP-sensitive potassium channels, leading to peripheral vasodilatation of arterioles and decreasing peripheral vascular resistance. The above processes result in reduced blood pressure. This drug has been discontinued by the FDA.|A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)

Pinacidil Basic Attributes

Molecular Weight：

245.32

Exact Mass：

245.32

EC Number：

262-294-9

NSC Number：

759588

DSSTox ID：

DTXSID7048249

ATC Code：

C - Cardiovascular system

HScode：

2933399090

Characteristics

PSA：

73.1

XLogP3：

2.81868

Appearance：

white solid

Density：

1.1402 (rough estimate)

Melting Point：

110-114 °C

Boiling Point：

378.29°C (rough estimate)

Refractive Index：

1.6500 (estimate)

Water Solubility：

ethanol: 14 mg/mL

Collision Cross Section：

165.2 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

wgk germany：

hazard class code：

22-36/37/38

safety instructions：

Marks：

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H302

Drug Information

MeSH：

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)|Agents that affect ION PUMPS; ION CHANNELS; ABC TRANSPORTERS; and other MEMBRANE TRANSPORT PROTEINS. (See all compounds classified as Membrane Transport Modulators.)

MeSH Entry Terms：

Anhydrous, Pinacidil

Pinacidil Use and Manufacturing

Uses

Antihypertensive.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:245.32
XLogP3:2.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:245.16404563
Monoisotopic Mass:245.16404563
Topological Polar Surface Area:73.1
Heavy Atom Count:18
Complexity:327
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes