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Eperisone

Eperisone structure

CAS No:
64840-90-0
Formula:
C17H25NO
Chemical Name:
Eperisone
Synonyms:
1-Propanone,1-(4-ethylphenyl)-2-methyl-3-(1-piperidinyl)-;1-(4-Ethylphenyl)-2-methyl-3-(1-piperidinyl)-1-propanone;Eperisone;4′-Ethyl-2-methyl-3-piperidinopropiophenone;(±)-Eperisone;124308-54-9
Categories:
Active Pharmaceutical Ingredients > Anesthetic Agents

Description

Eperisone is an antispastic agent used for treatment of diseases characterized by muscle stiffness and pain. It works by relaxing both skeletal muscles and vascularsmooth muscles, thus demonstrating avariety of effects such as reduction ofmyotonia, improvement of circulationand suppression of the pain reflex. Eperisone is a centrally acting muscle relaxant inhibiting the pain reflex pathway, having a vasodilator effect[1][2 [3].

1-(4-ethylphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one is an aromatic ketone that is N-propylpiperidine in which a hydrogen at positon 2 of the propyl group is replaced by a p-ethylbenzoyl group. It is a member of piperidines and an aromatic ketone.|Eperisone is an antispasmodic drug which relaxes both skeletal muscles and vascular smooth muscles, and demonstrates a variety of effects such as reduction of myotonia, improvement of circulation, and suppression of the pain reflex. It is not approved for use in the United States, but is available in other countries like India, South Korea, and Bangladesh.

Eperisone Basic Attributes

Molecular Weight：

259.39

Exact Mass：

259.39

DSSTox ID：

DTXSID5040671

ATC Code：

M - Musculo-skeletal system

HScode：

2933399090

Characteristics

PSA：

20.3

XLogP3：

3.49160

Density：

0.994 g/cm3

Melting Point：

170-172

Boiling Point：

386.8ºC at 760 mmHg

Flash Point：

137.4ºC

Drug Information

MeSH：

A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358) (See all compounds classified as Muscle Relaxants, Central.)|Drugs used to prevent SEIZURES or reduce their severity. (See all compounds classified as Anticonvulsants.)|Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)|Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)|A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)

MeSH Entry Terms：

(4'-ethyl-2-methyl-3-piperidino)propiophenone

Computed Properties

Molecular Weight:259.4
XLogP3:3.8
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:259.193614421
Monoisotopic Mass:259.193614421
Topological Polar Surface Area:20.3
Heavy Atom Count:19
Complexity:275
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It can act on the central nervous system and vascular smooth muscle at the same time, relieve skeletal muscle tension and improve blood flow. It can relieve skeletal muscle tension by improving various muscle tension symptoms, inhibiting spinal reflexes, and acting on the γ-system to reduce the sensitivity of muscle spindles. It can also improve blood flow by dilating blood vessels, thus blocking the vicious cycle of hypertonia → circulatory disorders → muscle pain → hypertonia from multiple aspects.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Eperisone Hydrochloride Tablets
Ingredients	Eperisone. Chemical name: 4,-ethyl-2-methyl-3-piperidinylpropiophenone hydrochloride Molecular weight: C17H25NO.HCl
Indication	A similar drug, tolperisone hydrochloride, has been reported to cause ocular accommodation disorders when used in combination with methoxycarbamol.
Specifications	50mg(film-coated)
Manufacturer	EIsai China Inc.

Registered Holders

EISAI CO. LTD

Belgium
Inactive