 Home > Encyclopedia > Aflatoxin B1

Aflatoxin B1

Aflatoxin B1 structure

CAS No:
1162-65-8
Formula:
C17H12O6
Chemical Name:
Aflatoxin B1
Synonyms:
1H,11H-Cyclopenta[c]furo[3′,2′:4,5]furo[2,3-h][1]benzopyran-1,11-dione,2,3,6a,9a-tetrahydro-4-methoxy-,(6aR,9aS)-;Cyclopenta[c]furo[3′,2′:4,5]furo[2,3-h][1]benzopyran-1,11-dione,2,3,6aα,9aα-tetrahydro-4-methoxy-;Cyclopenta[c]furo[3′,2′:4,5]furo[2,3-h][1]benzopyran-1,11-dione,2,3,6a,9a-tetrahydro-4-methoxy-,(6aR-cis)-;1-Cyclopentene-1-carboxylic acid,2-(3a,8a-dihydro-4-hydroxy-6-methoxyfuro[2,3-b]benzofuran-5-yl)-5-oxo-,δ-lactone;Cyclopenta[c]furo[3′,2′:4,5]furo[2,3-h][1]benzopyran-1,11-dione,2,3,6a,9a-tetrahydro-4-methoxy-,(6aR,9aS)-;(6aR,9aS)-2,3,6a,9a-Tetrahydro-4-methoxy-1H,11H-cyclopenta[c]furo[3′,2′:4,5]furo[2,3-h][1]benzopyran-1,11-dione;Aflatoxin B1;AFB1;(-)-Aflatoxin B1;NSC 529592;11003-08-0;13214-11-4;27261-02-5
Categories:
Analytical Chemistry > Standard

Description

Aflatoxin B1 (AFB1) is a Class 1A carcinogen, which is a secondary metabolite of Aspergillus flavus and A. parasiticus. Aflatoxin B1 (AFB1) mainly induces the transversion of G-->T in the third position of codon 249 of the p53 tumor suppressor gene, resulting in mutation[1][2].

Aflatoxin B1 Basic Attributes

Molecular Weight：

312.27

Exact Mass：

312.27

EC Number：

214-603-3

Characteristics

PSA：

71.1

XLogP3：

1.23 (est)

Appearance：

Aflatoxin b-1 appears as colorless to pale yellow crystals or white powder. Exhibits blue fluorescence. (NTP, 1992)

Density：

1.6±0.1 g/cm3

Melting Point：

268-269 °C

Boiling Point：

528.2±50.0 °C at 760 mmHg

Flash Point：

2 °C

Refractive Index：

1.687

Water Solubility：

In water, 16.14 mg/L at 25 deg C (est)

Storage Conditions：

2-8°C

Vapor Pressure：

2.65X10-10 mm Hg at 25 deg C (est)

Toxicity：

Oral-rat LD50：4.80 mg/kg; Oral-Mouse LD50: 9 mg/kg

Flammability characteristics：

Flammable; burning releases irritating fumes

Specific rotation：

D -558° (c = 0.1 in CHCl3); D -480° (c = 0.1 in DMF)

Safety Information

Packing level：

Hazard category：

6.1(a)

Transport codes：

UN 3462 6.1/PG 1

wgk germany：

hazard class code：

45-46-26/27/28-36-20/21/22-11-65-48/23/24/25-36/38-39/23/24/25-23/24/25

safety instructions：

53-45-36-26-16-24-7-62-36/37-28

RTECS Number：

GY1925000

Marks：

T+,T,Xn,F

Storage features：

Treasury is ventilated, low temperature and dry; stored separately from food materials

Stability/Shelf Life：

Aflatoxins b1, b2, g1, & g2 in water or chloroform solutions or in solid films were decomposed by UV irradiation.

Precautionary statement(s)：

P201-P260-P264-P280-P284-P301 + P310

Hazard Statements：

H300 + H310 + H330-H350

Toxicity

Toxicity class：

most toxic

Aflatoxin B1 Use and Manufacturing

Aflatoxin B1 is the major analogue of a family of bisfuranocoumarin mycotoxins produced by Aspergillus flavus and related species. Aflatoxin B1 exhibits a distinctive UV spectrum and blue fluorescence. Aflatoxins are among the most potent mycotoxins known but are in fact "pre-toxins", requiring metabolic activation to the toxic principle. Aflatoxins are found widely in nature in trace amounts, particularly in grains and nuts. The toxicity of these metabolites was first recognised in the 1950s and their structures elucidated in 1963. Aflatoxins have been extensively reviewed.

Computed Properties

Molecular Weight:312.27
XLogP3:1.6
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:1
Exact Mass:312.06338810
Monoisotopic Mass:312.06338810
Topological Polar Surface Area:71.1
Heavy Atom Count:23
Complexity:650
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Aflatoxin B1

SHANDONG LOOK CHEMICAL CO.,LTD Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Agrochemicals,Daily Chemicals,Catalysts & Chemical Auxiliary Agents,Extract,Inorganic Chemicals,Organic Intermediate,Pigment & Dyestuff,Polymer,Flavour & Fragrance,Basic Organic Chemicals,Pharmaceutical

Aflatoxin B1 1162-65-8

CAS No.: 1162-65-8

Grade: Industrial Grade

Content: 99%

Inquiry
HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

AFLATOXIN B1

CAS No.: 1162-65-8

Content: 99.00%

Inquiry
Shandong Ailike New Material Technology Contact Supplier

CN
2 YRS

Business licensed

Trader Supplier of API,Antibiotics,Anti cancer category

High quality and low price Aflatoxin B1 1162-65-8

CAS No.: 1162-65-8

Grade: pharmaceutical grade

Content: 99.9%

Inquiry