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Fosinopril

Fosinopril structure

CAS No:
98048-97-6
Formula:
C30H46NO7P
Chemical Name:
Fosinopril
Synonyms:
L-Proline,4-cyclohexyl-1-[2-[(R)-[(1S)-2-methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetyl]-,(4S)-;L-Proline,4-cyclohexyl-1-[[[2-methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetyl]-,[1[S*(R*)],2α,4β]-;L-Proline,4-cyclohexyl-1-[[(R)-[(1S)-2-methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetyl]-,(4S)-;(4S)-4-Cyclohexyl-1-[2-[(R)-[(1S)-2-methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetyl]-L-proline;Fosenopril;Fosinopril;Fozitec;97825-24-6;128947-97-7
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

ChEBI: A phosphinate ester-containing N-acyl derivative of (4S)-cyclohexyl-L-proline. It is used for the treatment of hypertension and heart failure. A pro-drug, it is hydrolysed in vivo to the corresponding phosphin nc acid, fosinoprilat, which is the active metabolite.

Fosinopril is an angiotensin-converting enzyme (ACE) inhibitor used in the therapy of hypertension and heart failure. Fosinopril is associated with a low rate of transient serum aminotransferase elevations during therapy and has been linked to rare instances of acute liver injury.|A phosphinic acid-containing angiotensin-converting enzyme inhibitor that is effective in the treatment of hypertension. It is a prodrug that is converted to its active metabolite fosinoprilat.

Fosinopril Basic Attributes

Molecular Weight：

563.66

Exact Mass：

563.66

EC Number：

1806241-263-5

DSSTox ID：

DTXSID1023079

ATC Code：

C - Cardiovascular system

HScode：

2942000000

Characteristics

PSA：

120.02000

XLogP3：

6.05920

Appearance：

Solid

Density：

1.173 g/cm3

Melting Point：

149-153°C

Boiling Point：

705.7ºC at 760 mmHg

Flash Point：

380.6ºC

Refractive Index：

1.531

Water Solubility：

Insoluble

Toxicity

Hepatotoxicity：

Fosinopril, like other ACE inhibitors, has been associated with a low rate of serum aminotransferase elevations (

Drug Information

LiverTox Summary：

Drug Classes：

Angiotensin-Converting Enzyme Inhibitors

MeSH：

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility. (See all compounds classified as Angiotensin-Converting Enzyme Inhibitors.)

MeSH Entry Terms：

Dynacil

Fosinopril Use and Manufacturing

mydriatic,

Computed Properties

Molecular Weight:563.7
XLogP3:6.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:15
Exact Mass:563.30118980
Monoisotopic Mass:563.30118980
Topological Polar Surface Area:110
Heavy Atom Count:39
Complexity:850
Undefined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Fosinopril 98.0%min Pharmaceutical Anti hypertensive drugs Cardiovascular drugs made in china

CAS No.: 98048-97-6

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