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Daidzein

Daidzein structure

CAS No:
486-66-8
Formula:
C15H10O4
Chemical Name:
Daidzein
Synonyms:
4H-1-Benzopyran-4-one,7-hydroxy-3-(4-hydroxyphenyl)-;Daidzein;Isoflavone,4′,7-dihydroxy-;7-Hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;4′,7-Dihydroxyisoflavone;7,4′-Dihydroxyisoflavone;Daidzeol;K 251b;NPI 031E;Isoaurostatin;FW 635I-1;Daidzin aglycone
Categories:
Pharmaceutical Intermediates > Antineoplastics

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Description

Daidzein is a soy isoflavone, which acts as a PPAR activator.

Solid

Daidzein is a member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by an additional hydroxy group at position 4'. It has a role as an antineoplastic agent, a phytoestrogen, a plant metabolite, an EC 3.2.1.20 (alpha-glucosidase) inhibitor and an EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor. It is a conjugate acid of a daidzein(1-).|Daidzein is an isoflavone extract from soy, which is an inactive analog of the tyrosine kinase inhibitor genistein. It has antioxidant and phytoestrogenic properties. (NCI)

Daidzein Basic Attributes

Molecular Weight：

254.24

Exact Mass：

254.24

EC Number：

207-635-4

UNII：

6287WC5J2L

DSSTox ID：

DTXSID9022310

NCI Thesaurus Code：

C1060

HScode：

29329990

Characteristics

PSA：

66.8

XLogP3：

2.5

Appearance：

White to off-white Powder

Density：

1.4±0.1 g/cm3

Melting Point：

323 °C (decomp)

Boiling Point：

512.8°C at 760 mmHg

Flash Point：

201.2±23.6 °C

Refractive Index：

1.699

Water Solubility：

H2O: insoluble ;DMSO: 10 mg/mL

Storage Conditions：

2-8°C

Vapor Pressure：

4.53E-10mmHg at 25°C

Collision Cross Section：

157.23 Å² [M+H]+ [CCS Type: DT, Method: stepped-field]|173.13 Å² [M+Na]+ [CCS Type: DT, Method: stepped-field]|162.33 Å² [M-H]- [CCS Type: DT, Method: stepped-field]|161.8 Å² [M-H]-

Safety Information

Hazard category：

IRRITANT

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/38

safety instructions：

24-26-37/39

RTECS Number：

DJ3100040

Marks：

Stability/Shelf Life：

Stable under normal shipping and handling conditions.

Precautionary statement(s)：

P280-P305 + P351 + P338-P337 + P313

Hazard Statements：

H315-H319

Drug Information

MeSH：

Compounds derived from plants, primarily ISOFLAVONES that mimic or modulate endogenous estrogens, usually by binding to ESTROGEN RECEPTORS. (See all compounds classified as Phytoestrogens.)

Metabolism/Metabolites：

Daidzein has known human metabolites that include (2S,3S,4S,5R)-3,4,5-Trihydroxy-6-[3-(4-hydroxyphenyl)-4-oxochromen-7-yl]oxyoxane-2-carboxylic acid and Dihydrodazein.

MeSH Entry Terms：

daidzein

Daidzein Use and Manufacturing

Uses

phytoestrogen

Use Classification：

Polyketides [PK] -> Flavonoids [PK12] -> Isoflavonoids [PK1205]

Computed Properties

Molecular Weight:254.24
XLogP3:2.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:254.05790880
Monoisotopic Mass:254.05790880
Topological Polar Surface Area:66.8
Heavy Atom Count:19
Complexity:382
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Ethanol

Dimethylformamide

Hydrochloric acid

Drug Function and Efficacy

Dilate the coronary arteries, femoral arteries, and cerebral arteries, increase cerebral blood flow, strengthen blood circulation in the limbs, reduce blood viscosity, weaken vascular resistance, reduce myocardial oxygen consumption, improve cardiac function, enhance microcirculation, increase peripheral blood flow, change blood rheology, lower blood pressure, and improve heart rhythm

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Daidzein Tablets
Ingredients	The main ingredient and chemical name of this product is: 4',7-dihydroxyisoflavone.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	50mg

Daidzein Tablets
Ingredients	The main ingredient and chemical name of this product is: 4',7-dihydroxyisoflavone.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	50mg
Manufacturer	Guangzhou Baiyunshan Guanghua Pharmaceutical Co., Ltd.

Daidzein
Manufacturer	Lepu Hengjiuyuan Pharmaceutical Co., Ltd.

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Registered Holders

Jiuquan Dadeli Pharmaceutical Co., Ltd.

China
Active
Lepu Hengjiuyuan Pharmaceutical Co., Ltd.

China
Active
Shanxi Aoer Pharmaceutical Co., Ltd.

China
Active

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