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Cephapirin sodium

Cephapirin sodium structure

CAS No:
24356-60-3
Formula:
C17H17N3O6S2.Na
Chemical Name:
Cephapirin sodium
Synonyms:
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[(acetyloxy)methyl]-8-oxo-7-[[2-(4-pyridinylthio)acetyl]amino]-,sodium salt (1:1),(6R,7R)-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-(hydroxymethyl)-8-oxo-7-[2-(4-pyridylthio)acetamido]-,acetate (ester),monosodium salt;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[(acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-,monosodium salt,(6R-trans)-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[(acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-,monosodium salt,(6R,7R)-;Cephapirin sodium;Sodium cephapirin;BLP 1322;7-[α-(4-Pyridylthio)acetamido]cephalosporanic acid sodium salt;Cefadyl;Cephatrexil;Cefatrexyl;Cefaprin sodium;Cefaloject;Sodium cefapirin;Cefapirin sodium;Cefa-Lak;Today;Brisfirina;Ambrocef;Cef-Lak;Piricef;Bristocef;NSC 179171
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Cephapirin sodium (Cefapirin sodium), a semisynthetic cephalosporin antibiotic, is bactericidal against strains of gram-positive and gram-negative bacteria[1].

Cephapirin sodium Basic Attributes

Molecular Weight：

445.45

Exact Mass：

445.03800

EC Number：

246-194-2

HScode：

2941906000

Characteristics

PSA：

179

Flash Point：

427.9ºC

Storage Conditions：

0-6°C

Safety Information

Transport codes：

NONH for all modes of transport

hazard class code：

36/37/38-42/43

safety instructions：

26-36

RTECS Number：

XI0382000

Marks：

Stability/Shelf Life：

If frozen immediately after reconstitution with sterile water for injection, bacteriostatic water for injection, 0.9% sodium chloride injection, or 5% dextrose injection, solutions retain their potency for up to 60 days at -15 deg C (5 deg F). After thawing at room temperature, solutions retain their potency for 12 hours at room temperature or for 10 days if refrigerated at 4 deg C (39 deg F).

Precautionary statement(s)：

P261-P280-P284-P304 + P340-P305 + P351 + P338-P342 + P311

Hazard Statements：

H315-H317-H319-H334-H335

Cephapirin sodium Use and Manufacturing

Methods of Manufacturing

Method for refining & purifying Cefapirin sodium, steps as follow: (1) Solvent preparation, 100kg concentrated hydrochloric acid added to 800kg of water to dubbed dilute acid solution and cooled to 0 C-10 C, spare; (2) the 60kg crude Cefapirin Sodium dissolved in the step (1) the dilute acid solution, stirred it until completely dissolved. After dissolution, 0.078kg of activated carbon was added, incubated at 40 C for decolorization for 20-30 minutes. filtered to remove activated carbon , Keep the filtrate, wash the Cefapirin Sodium on the activated carbon with 6 kg of purified water and combine the wash water with the filtered filtrate; (3) At 0-10 C, in step (2) filtrate slowly added the triethylamine to adjust the pH of filtrate to 3.5, then maintained the temperature and continued to stir the reaction for crystallization for 3h, then filtered to remove the mother liquor to obtain Cefapirin acid; (4) The step (3) Cefapirin acid was washed three times with 9kg purified water, and then was washed three times with 6kg acetone. After washing, 90kg of Cefapirin acid wet product dissolved in 1026kg Dichloromethane containing 54kg dimethylsulfoxide, and stirried to clarify; (5) At 0-10 C, 36kg sodium isooctanoate was added to the step (4) Cefapirin acid solution, stirred at 20 C for 80 minutes, cooled to 0-10 C, the mother liquor was filtered off to obtain Cefapirin sodium, and baked at 55 C for 6h to get the product. Refined and Purified Cefapirin sodium is white in color with an absorbance of 0.18, a purity of 99.17% and a maximum single impurity of 0.39%. All other impurities are less than 0.30% and total impurities are 0.83%. The yield is 94.5%.

Uses

antibacterial

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CAS No.: 24356-60-3

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Cefapirin sodium

CAS No.: 24356-60-3

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