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Isepamicin

Isepamicin structure

CAS No:
58152-03-7
Formula:
C22H43N5O12
Chemical Name:
Isepamicin
Synonyms:
D-Streptamine,O-6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-N1-[(2S)-3-amino-2-hydroxy-1-oxopropyl]-2-deoxy-;D-Streptamine,O-6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-N1-(3-amino-2-hydroxy-1-oxopropyl)-2-deoxy-,(S)-;O-6-Amino-6-deoxy-α-D-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-N1-[(2S)-3-amino-2-hydroxy-1-oxopropyl]-2-deoxy-D-streptamine;Sch 21420;HAPA-B;Isepamicin;Isepamicine;67479-40-7
Categories:
Active Pharmaceutical Ingredients > Antibiotics

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Isepamicin Basic Attributes

Molecular Weight：

569.6

Exact Mass：

569.60

EC Number：

261-143-4

DSSTox ID：

DTXSID1048380

Characteristics

PSA：

298

XLogP3：

-2.45

Density：

1.5±0.1 g/cm3

Boiling Point：

926.8±65.0 °C at 760 mmHg

Flash Point：

514.3±34.3 °C

Refractive Index：

1.641

Toxicity：

Intraperitoneal-mouse LDL0: 5000 mg/kg; intravenous-mouse LD50: 330 mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxide fumes

Safety Information

Storage features：

Warehouse ventilated, low temperature and dry

Toxicity

Toxicity class：

moderately toxic

Isepamicin Use and Manufacturing

Methods of Manufacturing

3h e, filter to remove the catalyst, concentrate the filtrate to dryness, chromatograph on silica gel, eluting with a mixture of chloroform, methanol and ammonium chloride. Compound (III) is obtained. After the compound (III) is reacted with trifluoroacetic acid, an excess of ether is added to produce a precipitate. The precipitate was collected by filtration, washed with ether, and then chromatographed on a silica gel column, eluted with chloroform-methanol-ammonium hydroxide (1:1.5:1). Obtained 0.352 g of isepamicin. It can be converted into isepamicin sulfate according to ordinary methods.

Uses

Semi-synthetic aminoglycoside antibiotics. Taking the medicine once a day is safe for people. Used for septicemia, chronic bronchitis, bronchiectasis infection, pneumonia, peritonitis caused by sensitive bacteria such as Staphylococcus aureus, Escherichia coli, pneumoniae, and Pseudomonas aeruginosa.

Computed Properties

Molecular Weight:569.6
XLogP3:-6.9
Hydrogen Bond Donor Count:12
Hydrogen Bond Acceptor Count:16
Rotatable Bond Count:9
Exact Mass:569.29082182
Monoisotopic Mass:569.29082182
Topological Polar Surface Area:298
Heavy Atom Count:39
Complexity:817
Undefined Atom Stereocenter Count:15
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Ammonium hydroxide

Trifluoroacetic acid

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Isepamicine >=98.0% API Antibiotics made in china

CAS No.: 58152-03-7

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Hangzhou Deli - raw material and API Contact Supplier

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Isepamicine Sulphate

CAS No.: 58152-03-7

Content: 98.00%

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