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Spiromesifen

Spiromesifen structure

Spiromesifen 

structure
  • CAS No:

    283594-90-1

  • Formula:

    C23H30O4

  • Chemical Name:

    Spiromesifen

  • Synonyms:

    Butanoic acid,3,3-dimethyl-,2-oxo-3-(2,4,6-trimethylphenyl)-1-oxaspiro[4.4]non-3-en-4-yl ester;Spiromesifen;Oberon;BSN 2060;Forbid

  • Categories:

    Analytical Chemistry  >  Standard

Description

ChEBI: A butenolide that is but-2-en-4-olide bearing a 2,4,6-trimethylphenyl group at position 3, a 3,3-dimethylbutyryloxy group at position 4 and a spiro-fused cyclopentyl ring at position 5.


Spiromesifen is a butenolide that is but-2-en-4-olide bearing a 2,4,6-trimethylphenyl group at position 3, a 3,3-dimethylbutyryloxy group at position 4 and a spiro-fused cyclopentyl ring at position 5. It has a role as an insecticide. It derives from a 1,3,5-trimethylbenzene and a 3,3-dimethylbutyric acid.

Spiromesifen Basic Attributes

370.48

370.48

608-196-5

N726NTQ5ZC

DTXSID1034929

White solid

Characteristics

52.6

4.55 (pH 2 and 7.5)

1.12g/cm3

98°

531.1ºC at 760mmHg

266.7ºC

1.549

In water, 0.13 mg/L at 20 deg C

0-6°C

1.5X10-4 mm Hg at 20 deg C

LD50 in rats (mg/kg): >2500 orally; >2000 dermally (24 hr);; LC50 (4 hr) in rats (mg/m3): >4873 by inhalation (Nauen)

Henry's Law constant = 5.6X10-4 atm-cu m/mole at 20 °C (est)

203.33 Ų [M+Na]+

Hydroxyl radical reaction rate constant = 7.6X10-11 cu cm/molec-sec at °C (est)|Ozone radical reaction rate constant = 2.1X10-17 cu cm/molec-sec at °C (est)

Safety Information

UN30779/PG3

2

43-50/53

36/37-60-61

Xi

P273-P280-P501

H317-H332-H410

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.|PESTICIDE DISPOSAL. Pesticide wastes are acutely hazardous. Improper disposal of excess pesticide, spray mixture, or rinsate is a violation of Federal Law. If these wastes cannot be disposed of by use according to label instructions, contact your State Pesticide or Environmental Control Agency, or the Hazardous Waste representative at the nearest EPA Regional Office for guidance. /Oberon 4 SC Insecticide/Miticide/|CONTAINER DISPOSAL. Non-refillable container. Do not reuse or refill this container. Triple rinse or equivalent. Then offer for recycling or reconditioning or puncture and dispose of in a sanitary landfill, or by other procedures approved by state and local authorities. /Oberon 4 SC Insecticide/Miticide/|Safe Disposal of Pesticides. The best way to dispose of small amounts of excess pesticides is to use them - apply them - according to the directions on the label. If you cannot use them, ask your neighbors whether they have a similar pest control problem and can use them. If all of the remaining pesticide cannot be properly used, check with your local solid waste management authority, environmental agency, or health department to find out whether your community has a household hazardous waste collection program or a similar program for getting rid of unwanted, leftover pesticides. These authorities can also inform you of any local requirements for pesticide waste disposal. /Residential users/|Safe Disposal of Pesticides. An empty pesticide container can be as hazardous as a full one because of residues left inside. Never reuse such a container. When empty, a pesticide container should be rinsed carefully three times and the rinsewater thoroughly drained back onto the sprayer or the container previously used to mix the pesticide. Use the rinsewater as a pesticide, following label directions. Replace the cap or closure securely. Dispose of the container according to label instructions. Do not puncture or burn a pressurized container like an aerosol - it could explode. Many communities have programs to recycle household waste such as empty bottles and cans. Do not recycle any pesticide containers, however, unless the recycling program specifically accepts pesticide containers and you follow the program's instructions for preparing the empty containers for collection. /Residential users/

|Warning|H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]|P261, P271, P272, P273, P280, P302+P352, P304+P312, P304+P340, P312, P321, P333+P313, P363, P391, and P501|Aggregated GHS information provided by 195 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Danger|H350: May cause cancer [Danger Carcinogenicity]|P201, P202, P260, P264, P270, P273, P281, P308+P313, P314, P391, P405, and P501

Mixers, loaders and other handlers must wear: Long-sleeved shirt and long pants, chemical resistant gloves (such as natural rubber, selection category A), and shoes plus socks. /Oberon 4 SC Insecticide/Miticide/|Applicators must wear: Long-sleeved shirt and long pants and shoes plus socks. /Oberon 4 SC Insecticide/Miticide/|... Restricted entry interval (REI) of 12 hours following application. PPE required for early entry to treated areas that is permitted under the Worker Protection Standard and that involves contact with anything that has been treated such as plants, soil or water, are: Coveralls over short sleeved shirt and short pants. Chemical resistant gloves (such as natural rubber, selection category A). Shoes plus socks. /Oberon 4 SC Insecticide/Miticide/|When handlers use closed systems or enclosed cabs in a manner that meets the requirements listed in the Worker Protection Standard (WPS) for agricultural pesticides [40 CFR 170.240 (d)(4-6)], the handler PPE requirements may be reduced or modified as specified in the WPS. /Oberon 4 SC Insecticide/Miticide/

Suitable Extinguishing Media: water spray, carbon dioxide (CO2), dry chemical. /Oberon 4 SC Insecticide/Miticide/|Fire Fighting Instructioins: Keep out of smoke. Fight fire from upwind position. Cool closed containers exposed to fire with water spray. Do not allow run-off from fire fighting to enter drains or water courses. Equipment or materials involved in pesticide fires may become contaminated. Wear self-contained breathing apparatus and protective suit. /Oberon 4 SC Insecticide/Miticide/

Do not contaminate water when cleaning equipment or disposing of equipment washwater. /Oberon 4 SC Insecticide/Miticide/|ACCIDENTAL RELEASE MEASURES. Keep unauthorized people away. Isolate hazard area. Avoid contact with spilled product or contaminated surfaces. ... Take up with absorbent material (e.g. sand, diatomaceous earth or a proprietary absorbent material). Keep in suitable, closed containers for disposal. Clean contaminated floors and objects thoroughly, observing environmental regulations. ... Use personal protective equipment. Avoid breathing vapors and avoid skin contact. Do not allow material to enter streams, sewers, or other waterways. /Oberon 4 SC Insecticide/Miticide/|If a spill occurs, clean it up promptly. Don't wash it away. Instead, sprinkle the spill with sawdust, vermiculite, or kitty litter. Sweep it into a plastic garbage bag, and dispose of it as directed on the pesticide product label./Residential users/|After Applying a Pesticide, Indoors or Outdoors. To remove pesticide residues, use a bucket to rinse tools or equipment three times, including any containers or utensils that you used when mixing the pesticide. Then pour the rinsewater into the pesticide sprayer and reuse the solution by applying it according to the pesticide product label directions. After applying any pesticide wash your hands and any other parts of your body that may have come in contact with the pesticide. To prevent tracking pesticides inside, remove or rinse your boots or shoes before entering your home. Wash any clothes that have been exposed to a lot of pesticide separately from your regular wash. /Residential users/

Use this product only in accordance with its labeling and with the Worker Protection Standard, 40 CFR part 170. /Oberon 4 SC Insecticide/Miticide/|This pesticide is toxic to fish and aquatic invertebrates. Do not contaminate surface water through spray drift. Do not apply directly to water, or to areas where surface water is present or to intertidal areas below the mean high water mark. /Oberon 4 SC Insecticide/Miticide/|Do not apply this product in a way that will contact workers or other persons, either directly or through drift. Only protected handlers may be in the same area during application. /Oberon 4 SC Insecticide/Miticide/|Do not enter or allow worker entry into treated areas during the restricted entry interval (REI) of 12 hours following application. /Oberon 4 SC Insecticide/Miticide/|For more Preventive Measures (Complete) data for Spiromesifen (13 total), please visit the HSDB record page.

SOIL: Soil samples taken 7 days after treatment of tea crops with spiromesifen at 112.5, 150, and 300 g/ha tested negative for the pesticide(1).

Toxicity

LC50 Rat inhalation >4873 mg/cu m/4 hr|LD50 Rat dermal >2000 mg/kg/24 hr|LD50 Rat oral >2500 mg/kg|LD50 Rat dermal >2,000 mg/kg|For more Non-Human Toxicity Values (Complete) data for Spiromesifen (6 total), please visit the HSDB record page.

Spiromesifen's production may result in its release to the environment through various waste streams; its use as a insecticide(1) will result in its direct release to the environment(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 34,000(SRC), determined from a structure estimation method(2), indicates that spiromesifen is expected to be immobile in soil(SRC). Volatilization of spiromesifen from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 5.6X10-4 atm-cu m/mole(SRC), based upon its vapor pressure, 1.5X10-4 mm Hg(3), and water solubility, 0.13 mg/L(3). However, adsorption to soil is expected to attenuate volatilization(SRC). Spiromesifen is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). Soil biodegradation half-lives of spiromesifen have been reported as 2.6 to 17.9 days(3).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 34,000(SRC), determined from a structure estimation method(2), indicates that spiromesifen is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 5.6X10-4 atm-cu m/mole(SRC), derived from its vapor pressure, 1.5X10-4 mm Hg(4), and water solubility, 0.13 mg/L(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 8.6 hours and 8.5 days, respectively(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 206 days if adsorption is considered(5). According to a classification scheme(6), an estimated BCF of 470(SRC), from its log Kow of 4.55(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is high(SRC). Spiromesifen hydrolysis half-lives are reported as 53.3, 24.8 and 4.3 days at pH 4, 7 and 9, respectively(4). Biodegradation of spiromesifen may take place in aquatic environments based on reported half-lives in soil of 2.6 to 17.9 days(4).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), spiromesifen, which has a vapor pressure of 1.5X10-4 mm Hg at 20 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase spiromesifen is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 5 hours(SRC), calculated from its rate constant of 7.6X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Vapor-phase spiromesifen is also degraded in the atmosphere by reaction with ozone(SRC); the half-life for this reaction in air is estimated to be 13 hours(SRC), calculated from its rate constant of 2.1X10-17 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Spiromesifen contains chromophores that absorb at wavelengths >290 nm(4) and therefore may be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of spiromesifen with photochemically-produced hydroxyl radicals has been estimated as 7.6X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 5 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). The rate constant for the vapor-phase reaction of spiromesifen with ozone has been estimated as 2.1X10-17 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(1). This corresponds to an atmospheric half-life of about 13 hours at an atmospheric concentration of 7X10+11 ozone molecules per cu cm(2). Spiromesifen hydrolysis half-lives are reported as 53.3, 24.8 and 4.3 days at pH 4, 7 and 9, respectively(3). Spiromesifen contains chromophores that absorb at wavelengths >290 nm(4) and therefore may be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 470 was calculated in fish for spiromesifen(SRC), using a log Kow of 4.55(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is high(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of spiromesifen can be estimated to be 34,000(SRC). According to a classification scheme(2), this estimated Koc value suggests that spiromesifen is expected to be immobile in soil.

The Henry's Law constant for spiromesifen is estimated as 5.6X10-4 atm-cu m/mole(SRC) derived from its vapor pressure, 1.5X10-5 mm Hg(1), and water solubility, 0.13 mg/L(1). This Henry's Law constant indicates that spiromesifen is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 8.6 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 8.5 days(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column(SRC). The estimated volatilization half-life from a model pond is 206 days if adsorption is considered(3). Spiromesifen's estimated Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). Spiromesifen is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(1).

Spiromesifen in/on unprocessed green tea (Camellia sinesis (L) O'Kuntze) leaf samples after foliar application. Plants were located at the Tea Experimental Farm, Dept of Tea Husbandry and Technology, CSK Himachal Pradesh Krishi Vishvavidyalaya Palampur (Himachal Pradesh), India(1).

Occupational exposure to spiromesifen may occur through inhalation and dermal contact with this compound at workplaces where spiromesifen is produced or used. Monitoring and use data indicate that the general population may be exposed to spiromesifen via ingestion of food treated with spiromesifen. (SRC).

Drug Information

In a metabolism study, BSN 2060-Phenyl- UL-14C (batch no. not provided, radiochemical purity: 100%, specific activity: 34.9 mCi/mmol) was administered intravenously to one male rhesus monkey at a dose level of 0.231 mg/kg (21.8 uCi/kg). In a second part of the study, BSN 2060 SC480 (batch no. K1 BRD (0037), ai 45.2%) containing BSN 2060-Phenyl-UL-14C, was applied to the skin of one male rhesus monkey at a dose of 0.191 mg/kg or 18.3 ug/sq cm (18.0 uCi/kg) for eight hours. Dosing via the intravenous route resulted in the excretion of the radiolabel largely in the urine. The percentage of the administered dose which was recovered in the urine, feces and cage debris/rinse samples was as follows: urine (54.32%), feces (13.08%), and cage debris/rinse (26.57%). A significant fraction of the dose was recovered in the cage debris/rinse. Although it was not definitive whether this radiolabel was from the urine or feces, a greater part of that fraction was recovered prior to any radiolabel being found in the feces. The 13% of the dose which was definitively recovered in the feces had likely passed through the biliary excretion route. Excretion was relatively rapid with greater than 70% of the administered dose recovered within the first 24 hours. Dermal application of the test material resulted in only limited absorption for the eight-hour exposure period, 3.31%. A large fraction of that total was recovered from the urine and cage debris/rinse showing that it is poorly absorbed through the skin layers.|In a metabolism study, BSN 2060 ([Dihydrofuranone-3-14C] BSN 2060, radiochemical purity: >97%, specific activity: 146.8 uCi/mg, lot no. 12513/1, non-labeled BSN 2060, purity: 99.5%, lot no. M00391) was administered to Wistar, Crl(W1)BR VAF/Plus rats orally by gavage. The study consisted of nine individual treatment protocols. In the excretion-balance portion, a preliminary study was performed in which 4 animals/sex were treated with 500 mg/kg of the test material. In 3 additional treatments, 4 animals/sex (unless otherwise noted) were treated with a single dose of 2 mg/kg, a single dose of 500 mg/kg (males only) or 14 daily unlabeled doses of 2 mg/kg each followed by a single dose of radiolabeled 2 mg/kg on the 15th day. Urine and feces were collected at specified intervals up to 72 hours post-dose. In the preliminary test, expired air was collected as well for the same time interval. In the 3 blood/plasma pharmacokinetics protocols, 12 animals/sex (unless otherwise noted) were dosed with a single dose of 2 mg/kg, a single dose of 500 mg/kg (males only) or 14 daily unlabeled doses of 2 mg/kg each followed by a single dose of radiolabeled 2 mg/kg on the 15th day. Blood was collected from 4 animals/sex at specified time points up to 120 hours post-dose. In the biliary excretion study, 4 males whose bile ducts had been cannulated received a single dose of 2 mg/kg and bile, urine and feces were collected at specified time points up to 48 hours post-dose. In the whole body autoradiography study, 6 males received a single dose of 2 mg/kg and one animal was euthanized at each specified time point up to 72 hours post-dose. For a single dose of 2 mg/kg, 39% of the administered dose was excreted in the urine and 55 to 57% in the feces with 88 to 90% of the dose being eliminated within the first 24 hours. Treatment with multiple doses of 2 mg/kg did not affect the ratio of radiolabel excreted in the urine and feces. Concentrations of residual radioactivity in the tissues were quite low at 72 hours post-dose. Treatment with 500 mg/kg of the test material resulted in a much lower percentage of the administered dose being excreted in the urine (7 to 9%) with the remainder recovered in the feces. Following a single dose of 2 mg/kg, the test material was rapidly if incompletely absorbed with the Cmax value in the blood achieved within 1 to 2 hours post-dose. Treatment with multiple doses of 2 mg/kg or a single dose of 500 mg/kg delayed the Tmax to 3 to 4 hours and 6 hours, respectively. The Cmax values and the concentration versus time curves [AUC(t)] indicated a disproportionately lower increase in the uptake of the radiolabel into the blood between the 2 mg/kg and 500 mg/kg treatments. At 500 mg/mg, these values were approximately 80% less than would be predicted by a proportionately linear increase. These data confirmed the reduced percentage of radiolabel which was absorbed at the 500 mg/kg treatment level in the excretion-balance profile. In the two 2 mg/kg treatment regimens, the Cmax and AUC(t) values for the females were less than those of the males with values ranging from 66 to 86% for Cmax and 43 to 55% for AUC(t) in comparison to the males. These data indicated that the females experienced less of an exposure to the test material than did the males. The whole-body autoradiograms qualitatively demonstrated the distribution of the radioactivity throughout the body. The highest areas of concentration at 1 hour post-dose were the gastrointestinal tract, bladder and blood within the heart. Overall tissue distribution appeared to be the highest at 4 hours post-dose with a progressive diminishment over the time-course of the study. At 48 hours post-dose, observable levels of radioactivity were present only in the gastrointestinal tract, kidneys and bladder. The test material was initially metabolized to the keto-enol by loss of the dimethylbutyric acid moiety. Both the phenyl and cyclopentyl rings were hydroxylated and the methyl groups on the phenyl ring were ultimately oxidized to a carboxylic acid. These metabolites were largely recovered in the bile and urine. The predominant moiety recovered in the feces was the unmetabolized test material. No conjugation with either glucuronic acid or sulfate was observed.

In livestock, spiromesifen is metabolized by the loss of the dimethylbutyric acid group to yield BSN 2060-enol. Further metabolism can include hydroxylation of BSN 2060- enol to yield BSN 2060-2-hydroxymethyl or BSN 2060-4-hydroxymethyl; hydroxylation of BSN 2060-enol to yield BSN 2060-3-pentanol; oxidation of BSN 2060-3-pentanol or BSN 2060-2- or -4-hydroxymethyl to give BSN 2060-2- or -4- hydroxymethyl-3-pentanol; oxidation of BSN 2060-4-hydroxymethyl to give BSN 2060-pentanone or BSN 2060-4-aldehyde; oxidation of BSN 2060-2- or 4- hydroxymethyl-3-pentanol to give BSN 2060-hydroxy-4-carboxy; and further hydroxylation of BSN 2060-4-hydroxymethyl-3-pentanol or BSN 2060-hydroxy-4- carboxy to give BSN 2060-dihydroxy-4-carboxy.|In a metabolism study, BSN 2060 ([Dihydrofuranone-3-14C] BSN 2060, radiochemical purity: >97%, specific activity: 146.8 uCi/mg, lot no. 12513/1, non-labeled BSN 2060, purity: 99.5%, lot no. M00391) was administered to Wistar, Crl(W1)BR VAF/Plus rats orally by gavage. The study consisted of nine individual treatment protocols. In the excretion-balance portion, a preliminary study was performed in which 4 animals/sex were treated with 500 mg/kg of the test material. In 3 additional treatments, 4 animals/sex (unless otherwise noted) were treated with a single dose of 2 mg/kg, a single dose of 500 mg/kg (males only) or 14 daily unlabeled doses of 2 mg/kg each followed by a single dose of radiolabeled 2 mg/kg on the 15th day. Urine and feces were collected at specified intervals up to 72 hours post-dose. ... The test material was initially metabolized to the keto-enol by loss of the dimethylbutyric acid moiety. Both the phenyl and cyclopentyl rings were hydroxylated and the methyl groups on the phenyl ring were ultimately oxidized to a carboxylic acid. These metabolites were largely recovered in the bile and urine. The predominant moiety recovered in the feces was the unmetabolized test material. No conjugation with either glucuronic acid or sulphate was observed.|The nature of the residue in livestock commodities is adequately understood based on metabolism studies conducted with lactating goats and laying hens. Based on these studies, spiromesifen is metabolized in all RACs by the loss of the dimethylbutyric acid group to yield BSN 2060-enol. Further metabolism can include hydroxylation of BSN 2060-enol to yield BSN 2060-2-hydroxymethyl or BSN 2060-4-hydroxymethyl; hydroxylation of BSN 2060-enol to yield BSN 2060-3-pentanol; oxidation of BSN 2060-3-pentanol or BSN 2060-2- or -4-hydroxymethyl to give BSN 2060-2- or -4- hydroxymethyl-3-pentanol; oxidation of BSN 2060-4-hydroxymethyl to give BSN 2060-pentanone or BSN 2060-4-aldehyde; oxidation of BSN 2060-2- or 4- hydroxymethyl-3-pentanol to give BSN 2060-hydroxy-4-carboxy; and further Page 30 of 56 hydroxylation of BSN 2060-4-hydroxymethyl-3-pentanol or BSN 2060-hydroxy-4- carboxy to give BSN 2060-dihydroxy-4-carboxy.

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/|/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/|/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/

3-(2,4,6-trimethylphenyl)-4-(3,3-dimethylbutylcarbonyloxy)-5-spirocyclo-pentyl-3-dihydrofuranon-2

Spiromesifen Use and Manufacturing

Uses

Insecticide.

Suspension concentrate (= flowable concentrate)|Forbid 4F Ornamental Insecticide/Miticide (Bayer Environmental Science) 45.2% Spiromesifen|Oberon 4 SC Insecticide/Miticide (Bayer Cropscience LP.) 45.2% Spiromesifen|Oberon 2SC Insecticide/Miticide (Bayer Cropscience LP.) 23.1% Spiromesifen|For more Formulations/Preparations (Complete) data for Spiromesifen (6 total), please visit the HSDB record page.

Technical by hplc/UV with DAD (diode array detector); impurities and product by hplc/UV with DAD. Residues in plants by gc/MSD, in soil and water by hplc ms/ms.

Agrochemicals -> Acaricides, Insecticides|Insecticides

Computed Properties

Molecular Weight:370.5
XLogP3:5.1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:370.21440943
Monoisotopic Mass:370.21440943
Topological Polar Surface Area:52.6
Heavy Atom Count:27
Complexity:621
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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