 Home > Encyclopedia > Rolipram

Rolipram

Rolipram structure

CAS No:
61413-54-5
Formula:
C16H21NO3
Chemical Name:
Rolipram
Synonyms:
2-Pyrrolidinone,4-[3-(cyclopentyloxy)-4-methoxyphenyl]-;4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone;ZK 62711;Rolipram;(±)-Rolipram;SB 95952;(R,S)-Rolipram;85416-74-6
Categories:
Biochemical Engineering > Inhibitors

Description

Rolipram is a selective phosphodiesterases PDE4 inhibitor with IC50s of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.

Rolipram is a member of the lclass of pyrrolidin-2-ones that is pyrrolidin-2-one bearing a 3-(cyclopentyloxy)-4-methoxyphenyl substituent at the 4-position. It is a type IV-specific phosphodiesterase (PDE4) inhibitor. It has a role as an antidepressant and an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor.|A phosphodiesterase inhibitor with antidepressant properties.|A phosphodiesterase 4 inhibitor with antidepressant properties.

Rolipram Basic Attributes

Molecular Weight：

275.34

Exact Mass：

275.34

EC Number：

262-771-1

NSC Number：

760125

DSSTox ID：

DTXSID3044124

HScode：

2933790090

Characteristics

PSA：

47.6

XLogP3：

2.2

Appearance：

white to off-white solid

Density：

1.2±0.1 g/cm3

Melting Point：

132 °C

Boiling Point：

472.7ºC at 760 mmHg

Flash Point：

239.7±28.7 °C

Refractive Index：

1.552

Water Solubility：

H2O: 0.2 mg/mL

Storage Conditions：

0-6°C

Toxicity：

LD50 oral in mouse: > 300mg/kg

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

3249

wgk germany：

hazard class code：

36/37/38-11

safety instructions：

26-36

RTECS Number：

UY5749237

Marks：

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (37.5%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 64 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems. (See all compounds classified as Antidepressive Agents.)|Compounds that specifically inhibit PHOSPHODIESTERASE 4. (See all compounds classified as Phosphodiesterase 4 Inhibitors.)

MeSH Entry Terms：

Rolipram

Rolipram Use and Manufacturing

Pharmacological tool for characterization of phosphodiesterase isoenzymes.

Computed Properties

Molecular Weight:275.34
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:275.15214353
Monoisotopic Mass:275.15214353
Topological Polar Surface Area:47.6
Heavy Atom Count:20
Complexity:341
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Rolipram

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Rolipram

CAS No.: 61413-54-5

Content: 99.00%

Inquiry
XI'AN HORLDEN BIO INDUSTRIES INC Contact Supplier

CN
3 YRS

Business licensed Certified factory

Manufactory Supplier of Chemical,Intermediate,5-amino-1mq,SLU-PP332,Tirzepatide,Peptide,KY19382,5-deazaflavin,Dihexa,Urolithin A

Best Price Pure 98% HPLC Roliprame Rolipram Powder CAS 61413-54-5

Unit Price: $220-240 /G FOB

CAS No.: 61413-54-5

Grade: HPLC Grade

Content: 99%

Inquiry