2,4-Dimethyl-6-nitroaniline
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2,4-Dimethyl-6-nitroaniline
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CAS No:
1635-84-3
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Formula:
C8H10N2O2
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Chemical Name:
2,4-Dimethyl-6-nitroaniline
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Synonyms:
Benzenamine,2,4-dimethyl-6-nitro-;2,4-Xylidine,6-nitro-;2,4-Dimethyl-6-nitrobenzenamine;2-Nitro-4,6-dimethylaniline;4,6-Dimethyl-2-nitroaniline;4-Amino-5-nitro-m-xylene;2,4-Dimethyl-6-nitroaniline;6-Nitro-2,4-xylidine;NSC 9816;2,4-Dimethyl-6-nitro-phenylamine
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CAS No:
Characteristics
71.8
2.4
1.220±0.06 g/cm3(Predicted)
68 °C
319.1±37.0 °C(Predicted)
146.8±26.5 °C
1.602
0.000346mmHg at 25°C
Safety Information
III
6.1
UN2811
3
20/21/22-36/37/38
26-37/39
Xn,Xi
P261-P280-P305 + P351 + P338
H302 + H312 + H332-H315-H319-H335
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 43 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
2,4-Dimethyl-6-nitroaniline Use and Manufacturing
4, 6-Dimethyl-2-nitro-phenylamine2, 4-Dimethylaniline (8.0 g, 66.0 mmol) was dissolved in acetic anhydride (50 mL), and nitric acid (5 mL) was slowly added in drops thereto at 0 Preparation 45: 5-Methyl-7-nitro-1H-indazoleStep A: 4, 6-Dimethyl-2-nitro-phenylamine; 2, 4-Dimethylaniline (8.0 g, 66.0 mmol) was dissolved in acetic anhydride (50 mL), and nitric acid (5 mL) was slowly added in drops thereto at 0° C. After stirring for 30 min, the mixture was diluted with ice water (200 mL). Conc. hydrochloric acid (10 mL) was added in drops thereto, and the resulting mixture was stirred under reflux for 4 h. After the reaction mixture was cooled to room temperature, the solvent was removed under reduced pressure. The residue was diluted with aqueous ammonium hydroxide solution. The resulting orange solid was filtered and dried to give the title compound (10.6 g, Yield 97percent).2, 4-Dimethylaniline (8.0 g, 66.0 mmol) was dissolved in acetic anhydride (50 mL), and nitric acid (5 mL) was slowly added in drops thereto at 0° C. After stirring for 30 min, the mixture was diluted with ice water (200 mL). Conc. hydrochloric acid (10 mL) was added in drops thereto, and the resulting mixture was stirred under reflux for 4 h. After the reaction mixture was cooled to room temperature, the solvent was removed under reduced pressure. The residue was diluted with aqueous ammonium hydroxide solution. The resulting orange solid was filtered and dried to give the title compound (10.6 g, Yield 97percent).