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Triethylenetetramine dihydrochloride

Triethylenetetramine dihydrochloride structure

CAS No:
38260-01-4
Formula:
C6H18N4.2ClH
Chemical Name:
Triethylenetetramine dihydrochloride
Synonyms:
1,2-Ethanediamine,N1,N2-bis(2-aminoethyl)-,hydrochloride (1:2);1,2-Ethanediamine,N,N′-bis(2-aminoethyl)-,dihydrochloride;Triethylenetetramine dihydrochloride;Trientine hydrochloride;Trien dihydrochloride;TTH;Cuprid;Syprine;Trientine dihydrochloride;N,N′-Bis-(2-aminoethyl)-1,2-ethanediamine dihydrochloride;Cufence
Categories:
Cosmetic Ingredient > Chelating

Description

white crystalline powder

Trientine hydrochloride is a secondary amino compound.|Trientine Hydrochloride is the hydrochloride salt form of a metal chelating agent with potential anti-angiogenic activity. Trientine chelates excess copper (Cu) ions in the body; the excess copper is subsequently removed from the body through the kidneys. As Cu is an essential cofactor for cuproenzymes, such as superoxide dismutase 1 (SOD1), depletion of copper may inhibit the activation of signal transduction pathways required for cellular proliferation and angiogenesis. In addition, trientine may inhibit copper-induced secretion of interleukin-8 (IL-8).|An ethylenediamine derivative used as stabilizer for EPOXY RESINS, as ampholyte for ISOELECTRIC FOCUSING and as chelating agent for copper in HEPATOLENTICULAR DEGENERATION.

Triethylenetetramine dihydrochloride Basic Attributes

Molecular Weight：

219.16

Exact Mass：

218.106506

EC Number：

253-854-3

UNII：

HC3NX54582

DSSTox ID：

DTXSID2057863

NCI Thesaurus Code：

C61987

ATC Code：

A16A

HScode：

2921290000

Characteristics

PSA：

76.1

XLogP3：

1.86940

Appearance：

white crystalline powder

Density：

0.958 g/cm3

Melting Point：

115-118 °C

Boiling Point：

266.5ºC at 760 mmHg

Flash Point：

143.3ºC

Storage Conditions：

0-6°C

Flammability characteristics：

Combustible in case of open flame or high heat; burning emits toxic nitrogen oxide fumes

Collision Cross Section：

138.8 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

RTECS Number：

KH8587085

Marks：

Storage features：

The warehouse is ventilated, low temperature and dry; store it separately from acids.

Explosive characteristics：

Corrosive to skin and cornea

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Drug Indication：

Cufence is indicated for the treatment of Wilson's disease in patients intolerant to D-Penicillamine therapy, in adults and children aged 5 years or older.

MeSH：

Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS. (See all compounds classified as Chelating Agents.)

MeSH Entry Terms：

Syprine

Triethylenetetramine dihydrochloride Use and Manufacturing

Uses

As thermosetting resin; epoxy curing agent; lubricating oil additive; analytical reagent for Cu, Ni.

Use Classification：

Human drugs -> Cufence -> EMA Drug Category|Other alimentary tract and metabolism products -> Human pharmacotherapeutic group|Human drugs -> Rare disease (orphan)|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:219.15
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:218.1065020
Monoisotopic Mass:218.1065020
Topological Polar Surface Area:76.1
Heavy Atom Count:12
Complexity:49.7
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

Material

Triethylenetetramine

Sodium chloride

Sulfuric acid

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Guide of Triethylenetetramine dihydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Material
Learn More Other Chemicals

Triethylenetetramine dihydrochloride

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