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1,3-Propanediamine, N1-(2,3-dihydro-1H-inden-2-yl)-N3,N3-diethyl-N1-phenyl-, hydrochloride (1:1)

1,3-Propanediamine, N1-(2,3-dihydro-1H-inden-2-yl)-N3,N3-diethyl-N1-phenyl-, hydrochloride (1:1) structure

CAS No:
33237-74-0
Formula:
C22H30N2.ClH
Chemical Name:
1,3-Propanediamine, N1-(2,3-dihydro-1H-inden-2-yl)-N3,N3-diethyl-N1-phenyl-, hydrochloride (1:1)
Synonyms:
1,3-Propanediamine,N1-(2,3-dihydro-1H-inden-2-yl)-N3,N3-diethyl-N1-phenyl-,hydrochloride (1:1);1,3-Propanediamine,N,N-diethyl-N′-2-indanyl-N′-phenyl-,monohydrochloride;1,3-Propanediamine,N-(2,3-dihydro-1H-inden-2-yl)-N′,N′-diethyl-N-phenyl-,monohydrochloride;Aprindine hydrochloride;Fiboran;MS 5075;Aspenon;Amidonal;Compd 83846;Fibocil;Ritmusin;NSC 284614;41363-19-3
Categories:
Organic Chemistry > Amides

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Description

Aprindine hydrochloride is a member of indanes.|A class Ib anti-arrhythmia agent used to manage ventricular and supraventricular arrhythmias.

1,3-Propanediamine, N1-(2,3-dihydro-1H-inden-2-yl)-N3,N3-diethyl-N1-phenyl-, hydrochloride (1:1) Basic Attributes

Molecular Weight：

358.95

Exact Mass：

358.21800

EC Number：

251-418-7

UNII：

PB5EKT7Q2V

DSSTox ID：

DTXSID5046726

Characteristics

PSA：

6.5

XLogP3：

5.19430

Density：

1.046g/cm3

Melting Point：

120-121 °C

Boiling Point：

450.9ºC at 760mmHg

Flash Point：

202ºC

Water Solubility：

H2O: >10mg/mL

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

22-36/37/38

safety instructions：

RTECS Number：

TX7386000

Marks：

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H302-H315-H319-H335

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 40 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)|A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS. (See all compounds classified as Voltage-Gated Sodium Channel Blockers.)

MeSH Entry Terms：

Amidonal

1,3-Propanediamine, N1-(2,3-dihydro-1H-inden-2-yl)-N3,N3-diethyl-N1-phenyl-, hydrochloride (1:1) Use and Manufacturing

Aprindine is a long-acting antiarrhythmic agent, effective when administered orally or intravenously in the treatment of ventricular arrhythmias of varying etiologies.

Computed Properties

Molecular Weight:358.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:8
Exact Mass:358.2175767
Monoisotopic Mass:358.2175767
Topological Polar Surface Area:6.5
Heavy Atom Count:25
Complexity:332
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product belongs to Class Ib antiarrhythmic drugs, inhibits the permeability of cell membrane to Na, but does not promote K outflow. It can slow down the conduction of various parts of the cardiac conduction system, reduce membrane reactivity, increase the excitation threshold, prolong the effective adaptation period of the atrium, atrioventricular node, His-Purkinje system (Purkinjes fibers) and ventricle, and block the forward and reverse conduction of the bypass pathway.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Apridin Hydrochloride Tablets
Ingredients	Aprindine hydrochloride. Chemical name: N, N'-diethyl-N'-2-indanyl-N'-phenyl-1,3-propylenediamine monohydrochloride.
Indication	When procaine or lidocaine is used for infiltration anesthesia at the same time, the drug should be discontinued or the dosage should be reduced for 2 to 3 days. It should not be used together with other antiarrhythmic drugs.
Specifications	25mg
Manufacturer	Hebei Huaweiman Pharmaceutical Co., Ltd.

Apridin Hydrochloride Tablets
Ingredients	Aprindine hydrochloride. Chemical name: N, N'-diethyl-N'-2-indanyl-N'-phenyl-1,3-propylenediamine monohydrochloride.
Indication	When procaine or lidocaine is used for infiltration anesthesia at the same time, the drug should be discontinued or the dosage should be reduced for 2 to 3 days. It should not be used together with other antiarrhythmic drugs.
Specifications	25mg
Manufacturer	China Resources Double-Crane Pharmaceutical Co., Ltd.

Apridin Hydrochloride Tablets
Ingredients	Aprindine hydrochloride. Chemical name: N, N'-diethyl-N'-2-indanyl-N'-phenyl-1,3-propylenediamine monohydrochloride.
Indication	When procaine or lidocaine is used for infiltration anesthesia at the same time, the drug should be discontinued or the dosage should be reduced for 2 to 3 days. It should not be used together with other antiarrhythmic drugs.
Specifications	25 mg

See More Related Drugs

Registered Holders

THE Central Pharmaceutical Co., Ltd.

China
Active
Tipr Pharmaceutical Co., Ltd.

China
Active

Latest News on 1,3-Propanediamine, N1-(2,3-dihydro-1H-inden-2-yl)-N3,N3-diethyl-N1-phenyl-, hydrochloride (1:1)

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Guide of 1,3-Propanediamine, N1-(2,3-dihydro-1H-inden-2-yl)-N3,N3-diethyl-N1-phenyl-, hydrochloride (1:1)

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Latest News
Learn More Other Chemicals

1,3-Propanediamine, N1-(2,3-dihydro-1H-inden-2-yl)-N3,N3-diethyl-N1-phenyl-, hydrochloride (1:1)

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