AG 1295
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AG 1295
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CAS No:
71897-07-9
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Formula:
C16H14N2
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Chemical Name:
AG 1295
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Synonyms:
6,7-DIMETHYL-2-PHENYLQUINOXALINE;AG 1295;TYROPHOSTIN AG1295;TYRPHOSTIN AG 1295;AG 1295 PLATELET-DERIVED GROW;TYRPHOSTIN AG 1295, 99+%;Quinoxaline, 6,7-dimethyl-2-phenyl-
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CAS No:
Description
AG 1295 is a selective platelet-derived growth factor receptor (PDGFR) tyrosine-kinase inhibitor. AG 1295 reduces neointimal formation in aortic allograft vasculopathy by inhibition of PDGFR-beta-triggered tyrosine phosphorylation[1][2].
6,7-dimethyl-2-phenylquinoxaline is a quinoxaline derivative.
Characteristics
25.8
3.92
1.1±0.1 g/cm3
121 °C
398.3±37.0 °C at 760 mmHg
172.4±17.8 °C
1.636
<0.3 [ug/mL]
−20°C
AG 1295 Use and Manufacturing
AG-1295 is a protein tyrosine kinase inhibitor. Antiproliferative agent used in the treatment of atherosclerosis, pulmonary fibrosis, and gliomas.
Computed Properties
Molecular Weight:234.29
XLogP3:3.6
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:234.115698455
Monoisotopic Mass:234.115698455
Topological Polar Surface Area:25.8
Heavy Atom Count:18
Complexity:272
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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