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5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine structure

CAS No:
23669-79-6
Formula:
C30H30N2O7
Chemical Name:
5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine
Synonyms:
5'-O-Dimethylterephthale-2'-deoxyuridine;5''-O-(4,4''-DIMETHOXYTRITYL)-2''-DEOXYURIDINE 99%;2'-Deoxy-5'-O-(4,4'-dimethoxytrityl)uridine;5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxyuridine;2'-Deoxy-5'-O-DMT-uridine;5'-DMT-dU;5'-O-[Bis(4-methoxyphenyl)benzyl]-2'-deoxyuridine;5'-O-DMT-2'-DEOXYURIDINE
Categories:
Biochemical Engineering > Nucleoside Drugs

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Description

solid

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine Basic Attributes

Molecular Weight：

530.58

Exact Mass：

530.57

EC Number：

245-814-9

Color/Form：

White to Off-white

HScode：

29349990

Characteristics

PSA：

107

XLogP3：

Appearance：

White to Off-white Powder

Density：

1.294±0.06 g/cm3(Predicted)

Melting Point：

120 °C

Refractive Index：

1.61

Water Solubility：

Soluble in acetonitrile at 20mg/ml

Storage Conditions：

−20°C

PKA：

9.39±0.10(Predicted)

Critical Temperature & Pressure：

Inert atmosphere,Store in freezer, under -20°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

22-26-36

Marks：

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

20/22-36/37/38

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine Use and Manufacturing

Methods of Manufacturing

The unprotected nucleoside (1 eq.) and LiTo a solution of 308-1 (22.80 g, 99.91 mmol) in anhydrous pyridine (200 mE) was added DMTC1 (37.24 g, 109.90 mmol), and the mixture stirred at 25° C. for 12 h. The reaction was quenched with a sat. NH4C1 solution (200 mE), and extracted with EA (3x200 mE). The combined organic layers were washed with brine (2x 100 mE), dried over anhydrous Na2SO4 and concentrated under reduced pressure. The residue was purified by column chromatography (PE:EA2: 1 to 0:1) to give the desired product (43.00 g, 72.94 mmol) as a yellow foam.

Uses

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

Computed Properties

Molecular Weight:530.6
XLogP3:3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:9
Exact Mass:530.20530130
Monoisotopic Mass:530.20530130
Topological Polar Surface Area:107
Heavy Atom Count:39
Complexity:835
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Learn More Other Chemicals

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine

SDS

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