4,6-Dichloro-2-methyl-5-pyrimidinamine
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4,6-Dichloro-2-methyl-5-pyrimidinamine
structure -
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CAS No:
39906-04-2
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Formula:
C5H5Cl2N3
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Chemical Name:
4,6-Dichloro-2-methyl-5-pyrimidinamine
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Synonyms:
5-Pyrimidinamine,4,6-dichloro-2-methyl-;Pyrimidine,5-amino-4,6-dichloro-2-methyl-;4,6-Dichloro-2-methyl-5-pyrimidinamine;5-Amino-4,6-dichloro-2-methylpyrimidine;4,6-Dichloro-2-methylpyrimidin-5-amine;2-Methyl-4,6-dichloro-5-aminopyrimidine;4,6-Dichloro-2-methylpyrimidin-5-ylamine
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CAS No:
4,6-Dichloro-2-methyl-5-pyrimidinamine Basic Attributes
178.02
178.02
419-110-9
DTXSID60353084
2933599090
Safety Information
NONH for all modes of transport
3
36/37/38
26-36
Xi
Irritant
P261-P305 + P351 + P338
H315-H319-H335
|Warning|H315 (98.08%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 53 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
4,6-Dichloro-2-methyl-5-pyrimidinamine Use and Manufacturing
General procedure: 10percent Pd/C(0.05) gwas added to the solution of substituted pyrimidine (4.48mmol) in ethyl acetate (EA, 20mL) in Parr hydrogenater. Then, replace the air with nitrogen three times, and react for 4hat room temperature in normal pressure. Filter the solution to remove Pd/C through Celite filter agent, the filtrate was concentrated to yield the intermediates 11a, b [46]. 5.4.1 4, 6-Dichloro-2-methyl-5-nitropyrimidine (11a) Pale solid; Yield: 84.0percent; MS (ESI) m/z: 177.94 [M+H]In a sealed tube was introduced 5-amino-2-methylpyrimidine-4, 6-diol (500 mg) of 1 and POCI3 (2.5 mL) and the system was purged with argon and was stirred at 1 10 °C for 20 h. The mixture was cooled to RT and was poured onto ice (5 mL). CH2CI2 (5 mL) was added and the pH was adjusted to 8 with 8 M NaOH. The layers were separated and the aqueous layer was extracted with CH2CI2 (1 .5 mL) The combined organic layers were washed with H
Used as an intermediate for the antihypertensive drug Moxonidine
Computed Properties
Molecular Weight:178.02
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Exact Mass:176.9860526
Monoisotopic Mass:176.9860526
Topological Polar Surface Area:51.8
Heavy Atom Count:10
Complexity:110
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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4,6-Dichloro-2-methyl-5-pyrimidinamine
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