Insulin-like Growth Factor-1 Receptor Inhibitor
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Insulin-like Growth Factor-1 Receptor Inhibitor
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CAS No:
468740-43-4
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Formula:
C25H26ClN5O3
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Chemical Name:
Insulin-like Growth Factor-1 Receptor Inhibitor
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Synonyms:
4-[[(2S)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]-3-[7-methyl-5-(4-morpholinyl)-1H-benzimidazol-2-yl]-2(1H)-pyridinone;BMS-536924;Insulin-like Growth Factor-1 Receptor Inhibitor;4-[[(2S)-2-(3-Chlorophenyl)-2-hydroxyethyl]aMino]-3-[7-Methyl-5-(4-Morpholinyl)-1H-benziMidazol-2-yl]-2(1H)-pyridinone BMS-536924;4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[4-methyl-6-(4-morpholinyl)-1H-benzimidazol-2-yl]- 2(1H)-pyridinone;CS-0117;HY-10262;BMS-536924 Insulin-like Growth Factor-1 Receptor Inhibitor
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CAS No:
Description
BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM.IC50 value: 100 nM (IGF-1R); 73 nM (IR) [1]Target: IGF-1R; IRin vitro: BMS-536924 also inhibits FAK and Lck with IC50 of 150 nM and 341 nM, respectively. BMS-536924 inhibits cellular proliferation and disrupts Akt and MAPK phosphorylation [1]. BMS-536924 inhibits IGF-I-stimulated IGF-1R signaling in MCF10A cells and blocks constitutive IGF-1R activity in CD8-IGF-1R-MCF10A. Preincubation of MCF10A cells with 1
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Insulin-like Growth Factor-1 Receptor Inhibitor
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