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Mk-2461.

Mk-2461. structure

CAS No:
917879-39-1
Formula:
C24H25N5O5S
Chemical Name:
Mk-2461.
Synonyms:
Mk-2461.;N-[(2R)-1,4-dioxan-2-ylMethyl]-N-Methyl{[5-(1-Methyl-1H-pyrazol-4-yl)-2-oxo-7-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-14-yl]aMino}sulfonaMide;N-((2R)-1,4-Dioxan-2-ylmethyl)-N-methyl-N'-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]sulfamide;Mk-2461 .N-[(2R)-1,4-dioxan-2-ylMethyl]-N-Methyl{[5-(1-Methyl-1H-pyrazol-4-yl)-2-oxo-7-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-14-yl]aMino}sulfonaMide
Categories:
Biochemical Engineering > Inhibitors

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Mk-2461. Basic Attributes

Molecular Weight：

495.557

Exact Mass：

495.158

UNII：

4200RD53XF

Characteristics

PSA：

124

XLogP3：

1.2

Density：

1.45 g/cm3

Boiling Point：

732.4°C at 760 mmHg

Flash Point：

396.7ºC

Mk-2461. Use and Manufacturing

MK-2461 is a novel ATP-competitive multitargeted kinase inhibitor that preferentially inhibits the activated c-Met receptor. MK-2461 is also a potent inhibitor of Ron, Flt1, Flt 3, PDGFRβ, and Mer receptors. Recent studies show that MK-2461 siginifciantly suppresses tumor growth of GTL-16 xenografts in mice and MK-2461 treatments effectively inhibit the growth of NIH3T3 tumors harboring c-Met single nucleotide mutants T3936C and T3997C.

Computed Properties

Molecular Weight:495.6
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:6
Exact Mass:495.15764009
Monoisotopic Mass:495.15764009
Topological Polar Surface Area:124
Heavy Atom Count:35
Complexity:895
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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MK-2461

CAS No.: 917879-39-1

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