2-(2-ETHYL-2,3-DIHYDRO-2-BENZOFURANYL)-1H-IMIDAZOLE
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2-(2-ETHYL-2,3-DIHYDRO-2-BENZOFURANYL)-1H-IMIDAZOLE
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CAS No:
189224-48-4
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Formula:
C13H14N2O
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Chemical Name:
2-(2-ETHYL-2,3-DIHYDRO-2-BENZOFURANYL)-1H-IMIDAZOLE
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Synonyms:
2-(2-ETHYL-2,3-DIHYDRO-2-BENZOFURANYL)-1H-IMIDAZOLE;KU14R;1H-IMidazole,2-(2-ethyl-2,3-dihydro-2-benzofuranyl)-
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CAS No:
Description
KU14R is a new I(3)-R antagonist, which selectively blocks the insulin secretory response to imidazolines.IC50 Value:Target: Insulin ReceptorA new I(3)-R antagonist, KU14R (2 (2-ethyl 2,3-dihydro-2-benzofuranyl)-2-imidazole), which selectively blocks the insulin secretory response to imidazolines. KU14R partially attenuated responses to Imidazole-4-acetic acid-ribotide (IAA-RP). The effects of KU14R on stimulus secretion-coupling in normal mouse islets and beta cells was compared by meas
2-(2-ethyl-3H-benzofuran-2-yl)-1H-imidazole is a member of 1-benzofurans.
2-(2-ETHYL-2,3-DIHYDRO-2-BENZOFURANYL)-1H-IMIDAZOLE Basic Attributes
214.26
214.110611
DTXSID50401725
Characteristics
37.9
2.10
White Solid
1.2±0.1 g/cm3
137-139ºC
428.1±34.0 °C at 760 mmHg
154.4±15.9 °C
1.595
Store at RT
3.89E-07mmHg at 25°C
2-(2-ETHYL-2,3-DIHYDRO-2-BENZOFURANYL)-1H-IMIDAZOLE Use and Manufacturing
Antagonist of the atypical imidazoline binding site (putative I 3 receptor) of pancreatic β -cells. Selectively blocks efaroxan-induced insulin secretion in vitro and in vivo .
Computed Properties
Molecular Weight:214.26
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:214.110613074
Monoisotopic Mass:214.110613074
Topological Polar Surface Area:37.9
Heavy Atom Count:16
Complexity:258
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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2-(2-ETHYL-2,3-DIHYDRO-2-BENZOFURANYL)-1H-IMIDAZOLE
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