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TAK-285

TAK-285 structure

CAS No:
871026-44-7
Formula:
C26H25ClF3N5O3
Chemical Name:
TAK-285
Synonyms:
TAK-285;TAK-285(TAK 285);N-[2-[4-[[3-Chloro-4-[3-(trifluoromethyl)phenoxy]phenyl]amino]-5H-pyrrolo[3,2-d]pyrimidin-5-yl]ethyl]-3-hydroxy-3-methylbutanamide;N-(2-(4-(3-Chloro-4-(3-(trifluoromethyl)phenoxy)phenylamino)-5H-pyrrolo[3,2-d]pyrimidin-5-yl)e
Categories:
Biochemical Engineering > Inhibitors

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TAK-285 Basic Attributes

Molecular Weight：

547.9566096

Exact Mass：

547.16

EC Number：

1533716-785-6

UNII：

70CCB438L6

DSSTox ID：

DTXSID10236136

Characteristics

PSA：

101

XLogP3：

4.4

Density：

1.39

Melting Point：

167-169℃

Boiling Point：

705.5±60.0°C at 760 mmHg

Drug Information

MeSH Entry Terms：

N-(2-(4-((3-chloro-4-(3-(trifluoromethyl)phenoxy)phenyl)amino)-5H-pyrrolo(3,2-d)pyrimidin-5-yl)ethyl)-3-hydroxy-3-methylbutanamide

TAK-285 Use and Manufacturing

TAK-285 is a novel dual HER2 and EGFR inhibitor with IC50 of 17 nM and 23 nM, respectively.

Computed Properties

Molecular Weight:548.0
XLogP3:4.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:9
Exact Mass:547.1598019
Monoisotopic Mass:547.1598019
Topological Polar Surface Area:101
Heavy Atom Count:38
Complexity:792
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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TAK-285

CAS No.: 871026-44-7

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CAS No.: 871026-44-7

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