IGF-1RInhibitorII,N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea
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IGF-1RInhibitorII,N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea
structure -
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CAS No:
196868-63-0
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Formula:
C18H16ClN3O2
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Chemical Name:
IGF-1RInhibitorII,N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea
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Synonyms:
IGF-1RInhibitorII,N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea;PQ401;N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)urea;IGF-1R Inhibitor II;N-(5-Chloro-2-methoxyphenyl)-N′-(2-methylquinolin-4-yl)urea;Urea, N-(5-chloro-2-Methoxyphenyl)-N'-(2-Methyl-4-quinolinyl)-;1-(5-Chloro-2-Methoxyphenyl)-3-(2-Methylquinolin-4-yl)urea;N-(5-chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)-
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CAS No:
Description
PQ401, a selective insulin-like growth factor-1 receptor blocker, is a novel diarylurea compound that inhibits IGF1R autophosphorylation with IC50 < 1 uM.IC50 Value: 12 uM (inhibited autophosphorylation of the IGF-IR in cultured human MCF-7 cells) [1]Target: IGF1Rin vitro: PQ401 inhibited autophosphorylation of the IGF-IR in cultured human MCF-7 cells with an IC50 of 12 micromol/L and autophosphorylation of the isolated kinase domain of the IGF-IR with an IC50 <1 micromol/L. In addition,
IGF-1RInhibitorII,N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea Basic Attributes
341.796
341.093109
2933499090
Characteristics
63.25000
5.35
white
1.4±0.1 g/cm3
426.1±45.0 °C at 760 mmHg
211.5±28.7 °C
1.709
DMSO: >10mg/mL
2-8°C
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IGF-1RInhibitorII,N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea
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